The peptide substance P (SP) shows a widespread distribution in both the central and
peripheral nervous systems, but it is also present in cells not belonging to the nervous …

In males but not in females, brain derived neurotrophic factor (BDNF) plays an obligatory
role in the onset and maintenance of neuropathic pain. Afferent terminals of injured …

The detection of environmental temperatures is critical for survival, yet inappropriate
responses to thermal stimuli can have a negative impact on overall health. The physiological …

Schwann cells are components of the peripheral nerve myelin sheath, which supports and
nourishes axons. Upon injury of the trigeminal nerve, Schwann cells are activated and …

Infection of the nervous system with the human immunodeficiency virus (HIV-1) can lead to
cognitive, motor and sensory disorders. HIV-related sensory neuropathy (HIV-SN) mainly …

Substance P (SP) is an important mediator of pro-inflammatory mechanisms in the skin. It
targets multiple cells such as keratinocytes, mast cells, and fibroblasts which are involved in …

Pain is complex. It is no longer acceptable to consider pain solely as a peripheral
phenomenon involving activation of nociceptive neurons. The contemporary understanding …

Key clinical features of cumulative trauma disorders include pain, muscle weakness, and
tissue fibrosis, although the etiology is still under investigation. Here, we characterized the …

Rationale Drug combinations are commonly used in pain management, which can produce
potent analgesic effects with reduced dosage and adverse effects. Objective This study was …

Sickle cell disease (SCD) is associated with acute vaso-occlusive crises that trigger painful
episodes and frequently involves ongoing, chronic pain. In addition, both humans and mice …