Antibiotic resistance is a major global health challenge and, worryingly, several key Gram
negative pathogens can become resistant to most currently available antibiotics. Polymyxins …

Antimicrobial peptides and proteins (APPs) are becoming increasingly important in targeting
multidrug-resistant (MDR) bacteria. APPs is a rapidly emerging area with novel molecules …

Background The pharmacokinetic/pharmacodynamic (PK/PD) relationship for polymyxin B
against Klebsiella pneumoniae infections is not known. Methods Dose-fractionation studies …

Antimicrobial resistance is a global public health threat, and the World Health Organization
(WHO) has announced a priority list of the most threatening pathogens against which novel …

The aim of this study was to design and characterize dry powder inhaler formulations of
ciprofloxacin and colistin co-loaded liposomes prepared by the ultrasonic spray-freeze …

Bacteriophage therapy is a promising alternative treatment to antibiotics, as it has been
documented to be efficacious against multidrug-resistant bacteria with minimal side effects …

Introduction: Pseudomonas aeruginosa (PA) is one of the most important causes of
healthcare-related infections among Gram-negative bacteria. The best therapeutic approach …

Objectives In the context of cystic fibrosis, Pseudomonas aeruginosa biofilms often develop
in the vicinity of airway mucus, which acts as a protective physical barrier to inhaled matter …

This study aimed to develop dry powder inhaler (DPI) combination formulations of
ciprofloxacin and colistin for use in respiratory infections. Effects of colistin on physical …

The polymyxins, colistin (also known as polymyxin E) and polymyxin B, have a unique and
interesting history. Originally introduced in the 1950s for the treatment of infections owing to …