Until recently we held the simple view that voltage-gated calcium channels consisted of an
α1 subunit, usually associated with auxiliary β subunits and α2δ subunits and that skeletal …

L-type Ca2+ channels are mediators of Ca2+ influx and the regulatory events accompanying
it and are pivotal in the function and dysfunction of ventricular cardiac myocytes. L-type …

Regulation of neuronal excitability and cardiac excitation-contraction coupling requires the
proper localization of L-type Ca 2+ channels. We show that the actin-binding protein α …

Hearing relies on Ca2+ influx-triggered exocytosis in cochlear inner hair cells (IHCs). Here
we studied the role of the Ca2+ channel subunit CaVβ2 in hearing. Of the CaVβ1–4 mRNAs …

Epac, exchange protein directly activated by cAMP, is emerging as a new regulator of
cardiac physiopathology. Although its effects are much less known than the classical cAMP …

Cav1. 2 Ca2+ channels, a type of voltage-gated L-type Ca2+ channel, are ubiquitously
expressed, and the predominant Ca2+ channel type, in working cardiac myocytes. Cav1. 2 …

In neurons, binding of calmodulin (CaM) or calcium-binding protein 1 (CaBP1) to the Ca V 1
(L-type) voltage-gated calcium channel IQ domain endows the channel with diametrically …

Quercetin, a flavonoid abundantly present in the Mediterranean diet, is considered a
vasodilator despite its recognized capability to stimulate vascular Ca V 1.2 channel current (I …

Ca2+ currents in neurons and muscle cells have been classified as being one of 5 types, of
which four, L, N, P/Q and R were said to be high threshold and one, T, was designated low …

Spinal cord injury leads to severe problems involving impaired motor, sensory, and
autonomic functions. After spinal injury there is an initial phase of hyporeflexia followed by …