[HTML][HTML] Advances in understanding N-glycosylation structure, function, and regulation in health and disease
S Esmail, MF Manolson - European journal of cell biology, 2021 - Elsevier
N-linked glycosylation is a post-translational modification crucial for membrane protein
folding, stability and other cellular functions. Alteration of membrane protein N-glycans is …
folding, stability and other cellular functions. Alteration of membrane protein N-glycans is …
N-glycosylation design and control of therapeutic monoclonal antibodies
The N-linked glycan profiles on recombinant monoclonal antibody therapeutics significantly
affect antibody biological functions and are largely determined by host cell genotypes and …
affect antibody biological functions and are largely determined by host cell genotypes and …
Controlling the time evolution of mAb N‐linked glycosylation‐Part II: Model‐based predictions
TK Villiger, E Scibona, M Stettler, H Broly… - Biotechnology …, 2016 - Wiley Online Library
N‐linked glycosylation is known to be a crucial factor for the therapeutic efficacy and safety
of monoclonal antibodies (mAbs) and many other glycoproteins. The nontemplate process of …
of monoclonal antibodies (mAbs) and many other glycoproteins. The nontemplate process of …
Application of multi-omics techniques for bioprocess design and optimization in Chinese hamster ovary cells
A Farrell, N McLoughlin, JJ Milne… - Journal of proteome …, 2014 - ACS Publications
Significant improvements in the productivity and quality of therapeutic proteins produced in
Chinese hamster ovary (CHO) cells have been reported since their establishment as host …
Chinese hamster ovary (CHO) cells have been reported since their establishment as host …
Hypoxia influences protein transport and epigenetic repression of CHO cell cultures in shake flasks
Shake flasks and bench‐top bioreactors are widely used for cell culture process
development, however, culture performances significantly differ between them. In order to …
development, however, culture performances significantly differ between them. In order to …
Melatonin regulation of transcription in the reversal of morphine tolerance: Microarray analysis of differential gene expression
YC Cheng, RY Tsai, YT Sung… - International …, 2019 - spandidos-publications.com
Tolerance and associated hyperalgesia induced by long-term morphine administration
substantially restrict the clinical use of morphine in pain treatment. Melatonin, a …
substantially restrict the clinical use of morphine in pain treatment. Melatonin, a …
Developing and Utilizing Novel Biofluid N-Glycan Profiling Methods for the Classification of Suspicious Mammogram Findings
C Blaschke - 2022 - medica-musc.researchcommons.org
Biofluids are a great source of biomarkers because they reflect the immune and metabolic
status of cells throughout the body and can be collected non-invasively. Changes in the …
status of cells throughout the body and can be collected non-invasively. Changes in the …
[图书][B] Elucidating the Molecular Mechanisms Involved in Assembly/Folding and Targeting V-ATPase a-subunit Isoforms to their Functional Destinations
S Esmail - 2017 - search.proquest.com
Abstract Vacuolar H+-ATPases (V-ATPases) are proton pumps distributed across
membranes of specialized cells and luminal compartments. V-ATPases in the plasma …
membranes of specialized cells and luminal compartments. V-ATPases in the plasma …