Genetic aspects of keratoconus: a literature review exploring potential genetic contributions and possible genetic relationships with comorbidities

E Loukovitis, K Sfakianakis, P Syrmakesi… - Ophthalmology and …, 2018 - Springer
Introduction Keratoconus (KC) is a complex, genetically heterogeneous, multifactorial
degenerative disorder that is accompanied by corneal ectasia which usually progresses …

Mechanisms of collagen crosslinking in diabetes and keratoconus

TB McKay, S Priyadarsini, D Karamichos - Cells, 2019 - mdpi.com
Collagen crosslinking provides the mechanical strength required for physiological
maintenance of the extracellular matrix in most tissues in the human body, including the …

Arabic Gum Could Alleviate the Aflatoxin B1-provoked Hepatic Injury in Rat: The Involvement of Oxidative Stress, Inflammatory, and Apoptotic Pathways

N Ahmed, SM El-Rayes, WF Khalil, A Abdeen… - Toxins, 2022 - mdpi.com
Aflatoxin B1 (AF) is an unavoidable environmental pollutant that contaminates food, feed,
and grains, which seriously threatens human and animal health. Arabic gum (AG) has …

Ameliorative effects of camel milk and silymarin upon aflatoxin B1 induced hepatic injury in rats

NH Hassaneen, SA Hemeda, AF El Nahas, SE Fadl… - Scientific Reports, 2023 - nature.com
Abstract Aflatoxin B1 (AFB1) poses a major risk to both human and animal health because it
contaminates food, feed, and grains. These dangerous effects can be mitigated using …

Biochemical markers and alterations in keratoconus

R Shetty, S D'Souza, P Khamar, A Ghosh… - The Asia-Pacific …, 2020 - journals.lww.com
Keratoconus (KC) is a corneal ectatic condition characterized by focal structural changes,
resulting in progressive thinning, biomechanical weakening, and steeping of the cornea that …

TNFRSF1B and TNF Variants Are Associated With Differences in Levels of Soluble Tumor Necrosis Factor Receptors in Patients With Severe COVID-19

I Fricke-Galindo, I Buendía-Roldán… - The Journal of …, 2022 - academic.oup.com
Background The impact of genetic variants in the expression of tumor necrosis factor-α (TNF-
α) and its receptors in coronavirus disease 2019 (COVID-19) severity has not been …

Tear Levels of Inflammatory Cytokines in Keratoconus: A Meta‐Analysis of Case‐Control and Cross‐Sectional Studies

H Zhang, X Cao, Y Liu, P Wang… - BioMed Research …, 2021 - Wiley Online Library
Purpose. To assess the tear levels of inflammatory cytokines in patients with keratoconus
(KC). Design. Systemic review and meta‐analysis. Methods. The following electronic …

Association of TNF-α-308 G> A (rs1800629) polymorphism with susceptibility of metabolic syndrome

D Ghareeb, AS Abdelazem, EM Hussein… - Journal of Diabetes & …, 2021 - Springer
Abstract Background Metabolic Syndrome (MetS) mainly comprises hyperglycemia,
hypertension and dyslipidemia, and has been proven to increase the risk for type 2 diabetes …

Serum 25-hydroxyvitamin D, selenium, zinc and copper in patients with keratoconus

S Zarei-Ghanavati, B Yahaghi… - Journal of Current …, 2020 - journals.lww.com
Purpose: To assess the possible association between keratoconus (KC) and serum levels of
25-hydroxyvitamin D (25OHD), Selenium (Se), Zinc (Zn), and Copper (Cu) and to compare it …

Identification of the immune-associated characteristics and predictive biomarkers of keratoconus based on single-cell RNA-sequencing and bulk RNA-sequencing

X Niu, M Xu, J Zhu, S Zhang, Y Yang - Frontiers in Immunology, 2023 - frontiersin.org
Background Whether keratoconus (KC) is an inflammatory disease is currently debated.
Hence, we aimed to investigate the immune-related features of KC based on single-cell …