The cyclic side chain of the amino acid proline confers unique conformational restraints on
its backbone and side chain dihedral angles. This affects two equilibria—one at the …

Amide bonds at the proline nitrogen are particularly susceptible to rotation, affording cis and
trans isomers. Installation of a stereochemically defined electron-withdrawing fluorine atom …

Efficacy of allergen-specific immunotherapy is often severely impaired by detrimental IgE-
mediated side effects of native allergen during vaccination. Here, we present the molecular …

The anomalous absence of cisPro stabilizing C α H α Xaa··· π Aro interactions at Xaa-Pro-
Aro exclusively when Aro is His, is understood by NMR structural analyses of model …

Aromatic rings exhibit defined interactions via the unique aromatic π face. Aromatic amino
acids interact favorably with proline residues via both the hydrophobic effect and aromatic …

We discover the presence of local van der Waals (vdW) interactions at the cis amide bond in
crystals of isobutyroyl–Pro–Val–OMe. By expanding this interaction volume, we demonstrate …

Tau misfolding, oligomerization, and aggregation are central to the pathology of Alzheimer's
disease (AD), chronic traumatic encephalopathy (CTE), frontotemporal dementia, and other …

Aspergillus terreus is an allergenic fungus, in addition to causing infections in both humans
and plants. However, the allergens in this fungus are still unknown, limiting the development …

Canonically, protein β-hairpin motifs are stabilized by intramolecular hydrogen bonds. Here,
we attempt to develop a rational design recipe for a miniature hairpin structure stabilized by …

We synthesized and carried out the conformational analysis of several hybrid dipeptides
consisting of an α‐amino acid attached to a quaternary glyco‐β‐amino acid. In particular, we …