Caenorhabditis elegans is a small nematode that can be maintained at low cost and
handled using standard in vitro techniques. Unlike toxicity testing using cell cultures, C …

It is now generally accepted that aging and eventual death of multicellular organisms is to a
large extent related to macromolecular damage by mitochondrially produced reactive …

Aging research has been very successful at identifying signaling pathways and
evolutionarily conserved genes that extend lifespan with the assumption that an increase in …

Cellular senescence—the permanent arrest of cycling in normally proliferating cells such as
fibroblasts—contributes both to age‐related loss of mammalian tissue homeostasis and acts …

Metformin, a biguanide drug commonly used to treat type-2 diabetes, has been noted to
extend healthspan of nondiabetic mice, but this outcome, and the molecular mechanisms …

Protein damage contributes prominently to cellular aging. To address whether this occurs at
a specific period during aging or accumulates gradually, we monitored the biochemical …

In many organisms, dietary restriction appears to extend lifespan, at least in part, by down-
regulating the nutrient-sensor TOR (Target Of Rapamycin). TOR inhibition elicits autophagy …

One of the many debated topics in ageing research is whether progeroid syndromes are
really accelerated forms of human ageing. The answer requires a better understanding of …

Caenorhabditis elegans is an exceptionally valuable model for aging research because of
many advantages, including its genetic tractability, short lifespan, and clear age‐dependent …

Nonenzymatic molecular modifications induced by reactive carbonyl species (RCS)
generated by peroxidation of membrane phospholipids acyl chains play a causal role in the …