Clinical advances in genetically-modified immune cell therapies, such as chimeric antigen
receptor T cell therapies, have raised hope for cancer treatment. The majority of these …

MicroRNAs (miRNAs) are post-transcriptional gene expression regulators with potential
therapeutic applications. miR-146a is a negative regulator of inflammatory processes in both …

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by
an abnormal expansion of CAG repeats. Although pathogenesis has been attributed to this …

Abstract Interleukin 17 (IL-17) is an important cytokine that can induce tissue inflammation
and is involved in the pathogenesis of numerous autoimmune diseases. However, the …

A new continuous fish cell line (CAM) has been successfully derived from the muscle tissues
of grass goldfish, Carassius auratus. The primary cell cultures were initiated by incomplete …

Growing evidence suggests that amyotrophic lateral sclerosis (ALS) is a multisystem
neurodegenerative disease that primarily affects motor neurons and, though less evidently …

Malignant melanoma (MM) represents the most dangerous form of skin cancer, and its
incidence is expected to rise in the coming time. However, therapy for MM is limited by low …

Ovarian cancer is the most lethal gynecologic cancer. Claudin-3 and-4, the receptors for
Clostridium perfringens enterotoxin (CPE), are overexpressed in more than 70% of these …

The primary regulatory gene for fatty acid synthesis, stearoyl-CoA desaturase 1 (SCD1), has
been linked to the progression of several malignancies. Its role in cervical cancer remains …

The episomal vector cannot integrate into the host cell chromosome, which has no potential
risk in gene therapy. However, the low level of transgene expression driven by episomal …