Triazoles are important five-membered heterocyclic scaffold due to their extensive biological
activities. This framework can be readily obtained in good to excellent yields on the …

Nature products have been extensively used in the discovery and development of new
drugs, as the most important source of drugs. The triazole ring is one of main …

The triazole heterocycle is a privileged scaffold in medicinal chemistry, since its structure is
present in a large number of biologically active molecules, including several drugs currently …

Click chemistry is perhaps the most powerful synthetic toolbox that can efficiently access the
molecular diversity and unique functions of complex natural products up to now. It enables …

Lapachol is an abundant prenyl naphthoquinone occurring in Brazilian Bignoniaceae that
was clinically used, in former times, as an antimalarial drug, despite its moderate effect …

Four groups, thirty-five compounds in total, of novel 1, 2, 3-triazole analogues of imidazo-[1,
2-a]-pyridine-3-carboxamides were designed and synthesized using substituted pyridine …

Abstract Nineteen 3, 5‐disubstituted‐isoxazole analogs were synthesized based on
nitrofuran scaffolds, by a [3+ 2] cycloaddition reaction between terminal acetylenes and 5 …

Chagas disease and leishmaniasis are neglected diseases of high priority as a public health
problem. Pharmacotherapy is based on the administration of a few drugs, which exhibit …

A series of 28 compounds, 3-nitro-1 H-1, 2, 4-triazole, were synthesized by click-chemistry
with diverse substitution patterns using medicinal chemistry approaches, such as …

Leishmania, one of the most important neglected tropical diseases, is endemic in several
regions of the world and hence regarded as a serious threat to public health. Major …