[HTML][HTML] Brain-derived neurotrophic factor and inflammation in depression: Pathogenic partners in crime?

GA Porter, JC O'Connor - World journal of psychiatry, 2022 - ncbi.nlm.nih.gov
Major depressive disorder is a debilitating disorder affecting millions of people each year.
Brain-derived neurotrophic factor (BDNF) and inflammation are two prominent biologic risk …

Dissecting the relationship between neuropsychiatric and neurodegenerative disorders

R Gupta, D Advani, D Yadav, RK Ambasta… - Molecular …, 2023 - Springer
Neurodegenerative diseases (NDDs) and neuropsychiatric disorders (NPDs) are two
common causes of death in elderly people, which includes progressive neuronal cell death …

Anxiolytic-like effect of succinic acid: a possible GABAergic intervention

MN Mia, SZ Smrity, MH Bappi, H Kamli, T Islam… - Food Bioscience, 2023 - Elsevier
In the modern era, physical and mental stress lead to anxiety at an alarming rate. Therefore,
searching for new lead compounds that deal with anxiety has a practical demand. Our study …

Astrocytic transcription factors REST, YY1, and putative microRNAs in Parkinson's disease and advanced therapeutic strategies

A Nassar, T Kodi, S Satarker, PC Gurram, SM Fayaz… - Gene, 2023 - Elsevier
Transcription factors (TF) and microRNAs are regulatory factors in astrocytes and are linked
to several Parkinson's disease (PD) progression causes, such as disruption of glutamine …

Involvement of indoleamine 2, 3-dioxygenase (IDO) and brain-derived neurotrophic factor (BDNF) in the neuroprotective mechanisms of ferulic acid against …

SB Mallik, J Mudgal, M Kinra, S Hall, GD Grant… - Metabolic Brain …, 2023 - Springer
Objective: Ferulic acid (FA) is a common food ingredient that is abundantly present in
various routinely consumed food and beverages. Like many cinnamic acid derivatives, FA …

Repressor element-1 binding transcription factor (REST) as a possible epigenetic regulator of neurodegeneration and MicroRNA-based therapeutic strategies

A Nassar, S Satarker, PC Gurram, D Upadhya… - Molecular …, 2023 - Springer
Neurodegenerative disorders (NDD) have grabbed significant scientific consideration due to
their fast increase in prevalence worldwide. The specific pathophysiology of the disease and …

Dopaminergic signaling as a plausible modulator of astrocytic toll-like receptor 4: a crosstalk between neuroinflammation and cognition

PC Gurram, S Manandhar, S Satarker… - CNS & Neurological …, 2023 - ingentaconnect.com
Neuroinflammation is one of the major pathological factors leading to Alzheimer's disease
(AD). The role of microglial cells in neuroinflammation associated with AD has been known …

The effect of calorie-restriction along with thylakoid membranes of spinach on the gut-brain Axis Pathway and oxidative stress biomarkers in obese women with …

N Nikrad, MA Farhangi, FP Fard Tabrizi… - Journal of Ovarian …, 2023 - Springer
Background Women with polycystic ovary syndrome (PCOS) have higher intestinal mucosal
permeability, leading to the lipopolysaccharide (LPS) leakage and endotoxemia. This, in …

Natural products targeting cellular processes common in Parkinson's disease and multiple sclerosis

X Xu, C Han, P Wang, F Zhou - Frontiers in Neurology, 2023 - frontiersin.org
The hallmarks of Parkinson's disease (PD) include the loss of dopaminergic neurons and
formation of Lewy bodies, whereas multiple sclerosis (MS) is an autoimmune disorder with …

Avanafil mediated dual inhibition of IKKβ and TNFR1 in an experimental paradigm of Alzheimer's disease: in silico and in vivo approach

P Chowdari Gurram, S Satarker, G Kumar… - Journal of …, 2023 - Taylor & Francis
In Alzheimer's disease pathology, inhibitors of nuclear factor kappa-β kinase subunit β
(IKKB) and Tumor necrosis factor receptor 1 (TNFR1) signaling are linked to …