Huntington's disease (HD) is a chronic neurodegenerative disorder caused by an expansion
of polyglutamine repeats in exon 1 of the Huntingtin gene. Transcriptional dysregulation …

The onset and mechanisms underlying neurodegenerative diseases remain uncertain. The
main features of neurodegenerative diseases have been related with cellular and molecular …

Huntington's disease (HD) is a devastating neurodegenerative disorder that is caused by an
abnormal expansion of CAG repeats in the Huntingtin (HTT) gene. Although the main …

Lamins are crucial proteins for nuclear functionality. Here, we provide new evidence
showing that increased lamin B1 levels contribute to the pathophysiology of Huntington's …

Methylation of cytosine in CpG dinucleotides is the major DNA modification in mammalian
cells that is a key component of stable epigenetic marks. This modification, which on the one …

Huntington's disease (HD) is an autosomal dominant disorder caused by an expansion in
the trinucleotide CAG repeat in exon-1 in the huntingtin gene, located on chromosome 4 …

Huntington's disease (HD) is a devastating neurodegenerative disorder caused by an
aberrant expansion of the CAG tract within the exon 1 of the HD gene, HTT. HD …

Huntington's disease (HD) is caused by an aberrant expansion of CAG repeats in the HTT
gene that mainly affects basal ganglia. Although striatal dysfunction has been widely studied …

Huntington's disease (HD) is a devastating and fatal monogenic neurodegenerative disorder
characterized by progressive loss of selective neurons in the brain and is caused by an …

While Huntington disease (HD) is caused solely by a polyglutamine expansion in the
huntingtin gene, environmental factors can influence HD onset and progression. Here, we …