Pyruvate kinase (PK), as one of the key enzymes for glycolysis, can encode four different
subtypes from two groups of genes, although the M2 subtype PKM2 is expressed mainly …

The tripartite motif (TRIM) protein family is a highly conserved group of E3 ligases with 77
members known in the human, most of which consist of a RING-finger domain, one or two B …

Abstract Purpose: Long non-coding RNAs (lncRNAs) play key roles in human cancers. Here,
FEZF1-AS1, a highly overexpressed lncRNA in colorectal cancer, was identified by lncRNA …

Cancer cells often encounter hypoxic and hypo-nutrient conditions, which force them to
make adaptive changes to meet their high demands for energy and various biomaterials for …

Pyruvate kinase M2 is a critical enzyme that regulates cell metabolism and growth under
different physiological conditions. In its metabolic role, pyruvate kinase M2 catalyzes the last …

Dysregulation of deubiquitination has been reported to contribute to carcinogenesis.
However, the function and mechanism of deubiquitinating enzyme 26S proteasome non …

Exploring novel anticancer drugs to optimize the efficacy may provide a benefit for the
treatment of colorectal cancer (CRC). Disulfiram (DSF), as an antialcoholism drug, is …

Tripartite motif (TRIM) family proteins are important effectors of innate immunity against viral
infections. Here we identified TRIM35 as a regulator of TRAF3 activation. Deficiency in or …

Hepatocellular carcinoma (HCC) is the fifth most prevalent cancer and is one of the leading
causes of cancer‐related death. The risk factors for HCC include cirrhosis, chronic viral …

Aberrated glucose metabolism is a key future of cancer cells. Unlike normal cells, tumor cells
favor glycolysis even in the presence of sufficient oxygen. Pyruvate kinase (PK), a key …