dATP elevation induces myocardial metabolic remodeling to support improved cardiac function
KN Mhatre, JD Murray, G Flint… - … of molecular and …, 2022 - pmc.ncbi.nlm.nih.gov
Hallmark features of systolic heart failure are reduced contractility and impaired metabolic
flexibility of the myocardium. Cardiomyocytes (CMs) with elevated deoxy ATP (dATP) via …
flexibility of the myocardium. Cardiomyocytes (CMs) with elevated deoxy ATP (dATP) via …
Motility Assay to Probe the Calcium Sensitivity of Myosin and Regulated Thin Filaments
C Liu, KM Ruppel, JA Spudich - Familial Cardiomyopathies: Methods and …, 2023 - Springer
Calcium-dependent activation of the thin filament mediated by the troponin-tropomyosin
complex is key in the regulation of actin-myosin based muscle contraction. Perturbations to …
complex is key in the regulation of actin-myosin based muscle contraction. Perturbations to …