Stem cell therapy for spinal cord injury

L Huang, C Fu, F Xiong, C He, Q Wei - Cell transplantation, 2021 - journals.sagepub.com
Traumatic spinal cord injury (SCI) results in direct and indirect damage to neural tissues,
which results in motor and sensory dysfunction, dystonia, and pathological reflex that …

Recent advances in the therapeutic uses of chondroitinase ABC

E Muir, F De Winter, J Verhaagen, J Fawcett - Experimental neurology, 2019 - Elsevier
Many studies, using pre-clinical models of SCI, have demonstrated the efficacy of
chondroitinase ABC as a treatment for spinal cord injury and this has been confirmed in …

Conductive hydrogels based on agarose/alginate/chitosan for neural disorder therapy

R Alizadeh, P Zarrintaj, SK Kamrava, Z Bagher… - Carbohydrate …, 2019 - Elsevier
Electroactive scaffolds derived from carbohydrate hydrogels were synthesized, resulting in a
large shift in the conductivity of chitosan (CS) from 10− 6 S/cm to about 10-3 S/cm, assigned …

Differentiation of human mesenchymal stem cells (MSC) to dopaminergic neurons: A comparison between Wharton's Jelly and olfactory mucosa as sources of MSCs

R Alizadeh, Z Bagher, SK Kamrava, M Falah… - Journal of chemical …, 2019 - Elsevier
The generation of dopaminergic neurons from stem cells is a potential therapeutic approach
to treat neurodegenerative disorders, such as Parkinson's disease. The current study aims to …

The comparative effects of mesenchymal stem cell transplantation therapy for spinal cord injury in humans and animal models: a systematic review and meta-analysis

LDV Johnson, MR Pickard, WEB Johnson - Biology, 2021 - mdpi.com
Simple Summary The effects of mesenchymal stem cell (MSC) transplants on functional
recovery after spinal cord injury have been compared in humans and animal models. Data …

Intrathecal delivery of adipose-derived mesenchymal stem cells in traumatic spinal cord injury: Phase I trial

M Bydon, W Qu, FM Moinuddin, CL Hunt… - Nature …, 2024 - nature.com
Intrathecal delivery of autologous culture-expanded adipose tissue-derived mesenchymal
stem cells (AD-MSC) could be utilized to treat traumatic spinal cord injury (SCI). This Phase I …

Co-administration of human adipose-derived stem cells and low-level laser to alleviate neuropathic pain after experimental spinal cord injury

A Sarveazad, A Janzadeh, G Taheripak… - Stem cell research & …, 2019 - Springer
Background Evidence has suggested that human adipose-derived stem cells (hADSCs) and
low-level laser has neuroprotective effects on spinal cord injury (SCI). Therefore, the …

Axonal growth inhibitors and their receptors in spinal cord injury: from biology to clinical translation

SS Chambel, CD Cruz - Neural Regeneration Research, 2023 - journals.lww.com
Axonal growth inhibitors are released during traumatic injuries to the adult mammalian
central nervous system, including after spinal cord injury. These molecules accumulate at …

Combine effect of Chondroitinase ABC and low level laser (660 nm) on spinal cord injury model in adult male rats

A Janzadeh, A Sarveazad, M Yousefifard, S Dameni… - Neuropeptides, 2017 - Elsevier
After spinal cord injury (SCI) there are many recoveries inhibiting factors such as chondroitin
sulfate proteoglycan (CSPG) and inflammation. The present study investigated the …

Protective effect of brain-derived neurotrophic factor and neurotrophin-3 overexpression by adipose-derived stem cells combined with silk fibroin/chitosan scaffold in …

WC Ji, M Li, WT Jiang, X Ma, J Li - Neurological Research, 2020 - Taylor & Francis
Objectives: Spinal cord injury (SCI) is a most debilitating traumatic injury, and cytotherapy is
a promising alternative treatment strategy. Here we investigated the effect and mechanism of …