The respiratory system, which consists of the lungs, trachea and associated vasculature, is
essential for terrestrial life. In recent years, extensive progress has been made in defining …

The mammalian respiratory system—the trachea and the lungs—arises from the anterior
foregut through a sequence of morphogenetic events involving reciprocal endodermal …

Regulatory networks that maintain functional, differentiated cell states are often dysregulated
in tumor development. Here, we use single-cell epigenomics to profile chromatin state …

Atrial fibrillation (AF) is known to be the most common supraventricular arrhythmia affecting
up to 1% of the general population. Its prevalence exponentially increases with age and …

The WGATAR motif is a common nucleotide sequence found in the transcriptional regulatory
regions of numerous genes. In vertebrates, these motifs are bound by one of six factors …

Epithelial organs, including the lung, are known to possess regenerative abilities through
activation of endogenous stem cell populations, but the molecular pathways regulating stem …

Although mutations in Kras are present in 21% of lung tumors, there is a high level of
heterogeneity in phenotype and outcome among patients with lung cancer bearing similar …

Mucinous adenocarcinoma of the lung is a subtype of highly invasive pulmonary tumors and
is associated with decreased or absent expression of the transcription factor NK2 homeobox …

Atrial fibrillation (AF) is the most common cardiac arrhythmia affecting 1–2% of the general
population. A number of studies have demonstrated that AF, and in particular lone AF, has a …

Molecular programs that mediate normal cell differentiation are required for oncogenesis
and tumor cell survival in certain cancers. How cell-lineage-restricted genes specifically …