Background Among the neglected tropical diseases, leishmaniasis continues to be
prevalent in many tropical and subtropical countries despite international, national, and local …

GC-MS for untargeted metabolomics is a well-established technique. Small molecules and
molecules made volatile by derivatization can be measured and those compounds are key …

American cutaneous leishmaniasis is a zoonotic disease caused by protozoans of the genus
Leishmania. The treatment of cutaneous leishmaniasis is unsatisfactory, thus, much …

Highly polar and ionic metabolites, such as sugars, most amino acids, organic acids or
nucleotides are not retained by conventional reversed-phase LC columns and polar …

Leishmaniasis is a group of neglected diseases whose clinical manifestations depend on
factors from the host and the pathogen. It is an important public health problem worldwide …

Leishmania (Viannia) braziliensis is an important Leishmania species circulating in several
Central and South American countries. Among Leishmania species circulating in Brazil …

Leishmaniasis is a vector-borne infectious disease caused by different species of protozoa
from the Leishmania genus. Classically, the disease can be classified into two main clinical …

In Brazil, Leishmania braziliensis is the main causative agent of the neglected tropical
disease, cutaneous leishmaniasis (CL). CL presents on a spectrum of disease severity with …

ABSTRACT With the World Health Organization reporting over 30,000 deaths and 200,000
to 400,000 new cases annually, visceral leishmaniasis is a serious disease affecting some …

It was recently hypothesized that Leishmania amastigotes could constitute a semi-quiescent
stage characterized by low replication and reduced metabolic activity. This concept …