Malaria vaccines: a new era of prevention and control

PE Duffy, JP Gorres, SA Healy, M Fried - Nature Reviews Microbiology, 2024 - nature.com
Malaria killed over 600,000 people in 2022, a death toll that has not improved since 2015.
Additionally, parasites and mosquitoes resistant to existing interventions are spreading …

Exploring FeLV-Gag-Based VLPs as a New Vaccine Platform—Analysis of Production and Immunogenicity

R Ortiz, A Barajas, A Pons-Grífols, B Trinité… - International Journal of …, 2023 - mdpi.com
Feline leukemia virus (FeLV) is one of the most prevalent infectious diseases in domestic
cats. Although different commercial vaccines are available, none of them provides full …

Nucleic Acid Vaccines Encoding Proteins and Virus-like Particles for HIV Prevention

F Tarrés-Freixas, B Clotet, J Carrillo, J Blanco - Vaccines, 2024 - mdpi.com
The development of HIV prophylactic vaccines is facing an impasse, since all phase IIb/III
clinical trials were halted in 2023 without demonstrating efficacy. Thus, the field is in need of …

[HTML][HTML] VLPs generated by the fusion of RSV-F or hMPV-F glycoprotein to HIV-Gag show improved immunogenicity and neutralizing response in mice

B Trinité, E Durr, A Pons-Grífols, G O'Donnell… - Vaccine, 2024 - Elsevier
Respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) vaccines have been
long overdue. Structure-based vaccine design created a new momentum in the last decade …

Virus-like particle-mediated delivery of structure-selected neoantigens demonstrates immunogenicity and antitumoral activity in mice

A Barajas, P Amengual-Rigo, A Pons-Grífols… - Journal of Translational …, 2024 - Springer
Background Neoantigens are patient-and tumor-specific peptides that arise from somatic
mutations. They stand as promising targets for personalized therapeutic cancer vaccines …

[HTML][HTML] Modulation of immune responses to liposomal vaccines by intrastructural help

D Damm, E Suleiman, JT Wagner, S Klessing… - European Journal of …, 2023 - Elsevier
The encapsulation of HIV-unrelated T helper peptides into liposomal vaccines presenting
trimers of the HIV-1 envelope glycoprotein (Env) on the surface (T helper liposomes) may …

Homologous sequential immunization using salmonella oral administration followed by an intranasal boost with ferritin-based nanoparticles enhanced the humoral …

Z Wang, T Zhang, F Jia, C Ge, Y He, Y Tian… - Microbiology …, 2023 - Am Soc Microbiol
The influenza virus continues to pose a great threat to public health due to the frequent
variations in RNA viruses. Vaccines targeting conserved epitopes, such as the extracellular …

Pseudotyping Improves the Yield of Functional SARS-CoV-2 Virus-like Particles (VLPs) as Tools for Vaccine and Therapeutic Development

AJ Zak, T Hoang, CM Yee, SM Rizvi, P Prabhu… - International Journal of …, 2023 - mdpi.com
Virus-like particles (VLPs) have been proposed as an attractive tool in SARS-CoV-2 vaccine
development, both as (1) a vaccine candidate with high immunogenicity and low …

Surface Functionalization of Virus-Like Particles via Bioorthogonal Click Reactions for Enhanced Cell-Specific Targeting

C Laomeephol, S Tawinwung, K Suppipat… - International Journal of …, 2024 - Elsevier
Surface functionalization of nano drug carriers allows for precise delivery of therapeutic
molecules to the target site. This technique involves attaching targeting molecules to the …

Investigation of the Electrokinetic Properties of HIV-Based Virus-Like Particles

T Wolf, C Grau, JF Rosengarten, J Stitz, J Wilkens… - Langmuir, 2024 - ACS Publications
The antigen density on the surface of HIV-based virus-like particles (VLPs) plays a crucial
role in the improvement of HIV vaccine potency. HIV VLPs consist of a dense protein core …