The number of genes known to cause human monogenic diseases is increasing rapidly. For
the extremely large, genetically and phenotypically heterogeneous group of intellectual …

Marine-terrestrial transition represents an important aspect of organismal evolution that
requires numerous morphological and genetic innovations and has been hypothesized to …

Abstract Cornelia de Lange Syndrome is a severe genetic disorder characterized by
malformations affecting multiple systems, with a common feature of severe mental …

Intellectual Disability (ID) disorders, defined by an IQ below 70, are genetically and
phenotypically highly heterogeneous. Identification of common molecular pathways …

Pattern formation is influenced by transcriptional regulation as well as by morphogenetic
mechanisms that shape organ primordia, although factors that link these processes remain …

Streptococcus pneumoniae, the pneumococcus, is a Gram-positive bacterium colonizing the
human upper respiratory tract as a commensal. However, pneumococci often transmigrate …

Neurons form elaborate networks by guiding axons and dendrites to appropriate
destinations. Neurites require information about the relative body axes during the initial …

Melanoma is rare in children, but its incidence appears to be increasing. Melanoma
accounts for the highest mortality among all skin cancer types. This disease is characterized …

Background: Planar cell polarity (PCP) originally referred to the coordination of global organ
axes and individual cell polarity within the plane of the epithelium. More recently, it has been …

Abstract Cornelia de Lange Syndrome (CdLS) is a rare genetic disorder affecting almost any
organ including the central nervous system, inducing a variable neurodevelopmental delay …