A synergetic turn in cognitive neuroscience of brain diseases

A Ibanez, ML Kringelbach, G Deco - Trends in Cognitive Sciences, 2024 - cell.com
Despite significant improvements in our understanding of brain diseases, many barriers
remain. Cognitive neuroscience faces four major challenges: complex structure–function …

Deep learning models reveal the link between dynamic brain connectivity patterns and states of consciousness

C Gomez, L Uhrig, V Frouin, E Duchesnay, B Jarraya… - Scientific Reports, 2024 - nature.com
Decoding states of consciousness from brain activity is a central challenge in neuroscience.
Dynamic functional connectivity (dFC) allows the study of short-term temporal changes in …

Whole-brain modelling of low-dimensional manifold modes reveals organising principle of brain dynamics

YS Perl, S Geli, E Pérez-Ordoyo, L Zonca, S Idesis… - bioRxiv, 2023 - biorxiv.org
The revolutionary discovery of resting state networks radically shifted the focus from the role
of local regions in cognitive tasks to the ongoing spontaneous dynamics in global networks …

The localization of coma

K Sharma, G Deco, A Solodkin - Cognitive Neuropsychology, 2024 - Taylor & Francis
Coma and disorders of consciousness (DoC) are common manifestations of acute severe
brain injuries. Research into their neuroanatomical basis can be traced from Hippocrates to …

Whole brain modelling for simulating pharmacological interventions on patients with disorders of consciousness

I Mindlin, R Herzog, L Belloli, D Manasova… - Communications …, 2024 - nature.com
Disorders of consciousness (DoC) represent a challenging and complex group of
neurological conditions characterised by profound disturbances in consciousness. The …

Re-awakening the brain: Forcing transitions in disorders of consciousness by external in silico perturbation

PC Dagnino, A Escrichs… - PLOS Computational …, 2024 - journals.plos.org
A fundamental challenge in neuroscience is accurately defining brain states and predicting
how and where to perturb the brain to force a transition. Here, we investigated resting-state …

Functional hierarchies in brain dynamics characterized by signal reversibility in ferret cortex

S Idesis, S Geli, J Faskowitz, J Vohryzek… - PLOS Computational …, 2024 - journals.plos.org
Brain signal irreversibility has been shown to be a promising approach to study neural
dynamics. Nevertheless, the relation with cortical hierarchy and the influence of different …

Psychedelics and disorders of consciousness: the current landscape and the path forward

P Cardone, N Alnagger, J Annen… - Neuroscience of …, 2024 - academic.oup.com
Modern medicine has been shaken by the surge of psychedelic science that proposes a
new approach to mitigate mental disorders, such as depression and post-traumatic stress …

Modelling low-dimensional interacting brain networks reveals organising principle in human cognition

Y Sanz Perl, S Geli, E Pérez-Ordoyo, L Zonca… - Network …, 2025 - direct.mit.edu
The discovery of resting state networks shifted the focus from the role of local regions in
cognitive tasks to the ongoing spontaneous dynamics in global networks. Recently, efforts …

Deciphering network dysregulations and temporo-spatial dynamics in disorders of consciousness: insights from minimum spanning tree analysis

Y Dai, Q He, S Wang, T Cao, X Chai, N Wang… - Frontiers in …, 2024 - frontiersin.org
Objectives The neural mechanism associated with impaired consciousness is not fully clear.
We aim to explore the association between static and dynamic minimum spanning tree …