We present SpotOn, a web server to identify and classify interfacial residues as Hot-Spots
(HS) and Null-Spots (NS). SpotON implements a robust algorithm with a demonstrated …

Disruption of protein–protein interactions is medicinally important. Interface helices may be
mimicked in helical probes featuring enhanced rigidities, binding to protein targets …

Understanding protein–protein interactions (PPIs) is fundamental to describe and to
characterize the formation of biomolecular assemblies, and to establish the energetic …

Severe Acute Respiratory Syndrome CoronaVirus-2 (SARS-CoV-2) is composed of four
structural proteins and several accessory non-structural proteins. SARS-CoV-2's most …

Understanding protein-protein interactions is a key challenge in biochemistry. In this work,
we describe a more accurate methodology to predict Hot-Spots (HS) in protein-protein …

Hot spots are interfacial core areas of binding proteins, which have been applied as targets
in drug design. Experimental methods are costly in both time and expense to locate hot spot …

Biological systems rely on the establishment of interactions between biomolecules, which
take place in the aqueous environment of the cell. It was already demonstrated that a small …

The aim of this study was to evaluate hypocholesterolemic potential of phytoconstituents of
ethanolic seed extract of cumin (Cuminum cyminum L.) by assessments of interaction …

Due to the importance of hot-spots (HS) detection and the efficiency of computational
methodologies, several HS detecting approaches have been developed. The current paper …

The study of functional residues (FRs) is essential for understanding protein functions and
biological processes. The amino acid network (AAN) has become an emerging paradigm for …