Endoplasmic reticulum (ER)-associated protein degradation (ERAD) eliminates misfolded or
unassembled proteins from the ER. ERAD targets are selected by a quality control system …

Presumably because of the selective pressure exerted by the immune system, many viruses
have evolved proteins that interfere with antigen presentation by major histocompatibility …

The cell surface display of peptides by MHC class I molecules to lymphocytes provides the
host with an important surveillance mechanism to protect against invading pathogens …

Proteins that are misfolded in the endoplasmic reticulum are transported back into the
cytosol for destruction by the proteasome. This retro-translocation pathway has been co …

The coordinated activities of innate and adaptive immunity are critical for effective protection
against viruses. To counter this, some viruses have evolved sophisticated strategies to …

Major mechanisms for the recognition of pathogens by immune cells have evolved to
employ classical and non-classical major histocompatibility complex class I (MHC I) …

CD8+ T cells are the main effector cells for the immune control of cytomegaloviruses. To
subvert this control, human and mouse cytomegaloviruses each encode a set of immune …

Adaptive immunity is shaped by a selection of peptides presented on major
histocompatibility complex class I (MHC I) molecules. The chaperones Tapasin (Tsn) and …

Human cytomegalovirus (CMV) remains the major infectious cause of birth defects as well
as an important opportunistic pathogen. Individuals infected with CMV mount a strong …

The endoplasmic reticulum (ER) is the major site of membrane biogenesis in most
eukaryotic cells. As the entry point to the secretory pathway, it handles more than 10,000 …