Biological activity of selected natural and synthetic terpenoid lactones

AK Surowiak, L Balcerzak, S Lochyński… - International journal of …, 2021 - mdpi.com
Terpenoids with lactone moieties have been indicated to possess high bioactivity. Certain
terpenoid lactones exist in nature, in plants and animals, but they can also be obtained by …

[HTML][HTML] Antioxidants activities of phytochemicals perspective modulation of autophagy and apoptosis to treating cancer

KR Ahmed, MM Rahman, MN Islam, MMH Fahim… - Biomedicine & …, 2024 - Elsevier
The study of chemicals extracted from natural sources should be encouraged due to the
significant number of cancer deaths each year and the financial burden imposed by this …

RETRACTED: Therapeutic effects of chrysin in a rat model of traumatic brain injury: A behavioral, biochemical, and histological study

M Rashno, A Sarkaki, Y Farbood, M Rashno… - 2019 - Elsevier
The editors have been alerted to concerns about the integrity of the images shown in
Figures 4, 5 and 6, which allegedly contain suspected image duplications, as detailed here …

Chrysin attenuates traumatic brain injury-induced recognition memory decline, and anxiety/depression-like behaviors in rats: Insights into underlying mechanisms

M Rashno, S Ghaderi, A Nesari, L Khorsandi… - …, 2020 - Springer
Rationale Cortical and hippocampal neuronal apoptosis and neuroinflammation are
associated with behavioral deficits following traumatic brain injury (TBI). Objectives The …

Lipase-mediated Baeyer–Villiger oxidation of benzylcyclopentanones in ester solvents and deep eutectic solvents

M Mazur, T Janeczko, W Gładkowski - Scientific Reports, 2022 - nature.com
This work presents the chemo-enzymatic Baeyer–Villiger oxidation of α-
benzylcyclopentanones in ester solvents as well as deep eutectic solvents (DES). In the first …

Inhibitory regulation of purple sweet potato polysaccharide on the hepatotoxicity of tri-(2, 3-dibromopropyl) isocyanate

Z Qi, Z Le, F Han, Y Feng, M Yang, C Ji… - International Journal of …, 2022 - Elsevier
Abstract Tri-(2, 3-dibromopropyl) isocyanate (TBC), a new emerged persistent organic
pollutant, is widely used in fields of flame retardant, textile, rubber and plastic with strong …

SCP-7, a germacrane-type sesquiterpene lactone derivative, induces ROS-mediated apoptosis in NSCLC cells in vitro and in vivo

YY Zhang, H Ren, QL Yan, YL Li, Q Liu, GD Yao… - European Journal of …, 2022 - Elsevier
Scabertopin (SCP), an abundant germacrane-type sesquiterpene lactone (SLC) isolated
from Elephantopus scaber, was selected as a reference compound for modification and …

Preparation of enantiomeric β-(2′, 5′-dimethylphenyl) bromolactones, their antiproliferative activity and effect on biological membranes

W Gładkowski, A Włoch, A Pawlak, A Sysak… - Molecules, 2018 - mdpi.com
Three novel enantiomeric pairs of bromolactones possesing a 2, 5-dimethylphenyl
substituent at the β-position of the lactone ring have been synthesized from corresponding …

Chemoenzymatic synthesis of enantiomeric, bicyclic δ-halo-γ-lactones with a cyclohexane ring, their biological activity and interaction with biological membranes

M Mazur, A Włoch, F Bahri, H Pruchnik, A Pawlak… - Biomolecules, 2020 - mdpi.com
Starting from 1-acetyl-1-cyclohexene, three enantiomeric pairs (ee≥ 99%) of bicyclic δ-halo-
γ-lactones with cyclohexane ring were obtained in five-step synthesis. The key …

Biotechnological approach for the production of enantiomeric hydroxylactones derived from benzaldehyde and evaluation of their cytotoxic activity

M Mazur, A Kudrynska, A Pawlak, B Hernandez-Suarez… - Catalysts, 2020 - mdpi.com
The β-aryl-δ-halo-γ-lactones are known for their antiproliferative activity towards numerous
cancer cell lines. The aim of this study was to obtain in the biotransformation process new β …