Abstract The Genetics Core of the Alzheimer's Disease Neuroimaging Initiative (ADNI),
formally established in 2009, aims to provide resources and facilitate research related to …

Flavonoid intake is negatively correlated with the incidence of some chronic diseases
including cardiovascular diseases, type II diabetes, neurodegenerative diseases, and …

Drug repositioning has been regarded as one of the most promising strategies for
translational medicine. Common efforts to find new uses for existing drugs depend on text …

Computational analysis of human-virus protein-protein interaction (PPI) data is an effective
way toward systems understanding the molecular mechanism of viral infection. Previous …

Background The identification of new uses for existing drug therapies has the potential to
identify treatments for comorbid conditions that have the added benefit of glycemic control …

Psoriasis is a genetically-regulated, T lymphocyte-mediated autoimmune skin disease that
causes systemic damage, seriously affecting patient quality of life and survival. Psoriasis …

Increased investments and development of new technologies in drug discovery have barely
improved the outcome of medicinal entities in the drug discovery market from a long time …

Highlights•Evolutionary insights are helpful in various medical fields.•HARs are significantly
enriched with neurological disorder-associated genes.•Approved drugs target nearly twice …

In the modern drug discovery pipeline, identification of novel drug targets is a critical step.
Despite rapid progress in developing biomedical techniques, it is still a great challenge to …

Due to synergistic effects, combinatorial drugs are widely used for treating complex
diseases. However, combining drugs and making them synergetic remains a challenge …