Neurophysiological endophenotypes of schizophrenia: the viability of selected candidate measures

BI Turetsky, ME Calkins, GA Light, A Olincy… - Schizophrenia …, 2007 - academic.oup.com
In an effort to reveal susceptibility genes, schizophrenia research has turned to the
endophenotype strategy. Endophenotypes are characteristics that reflect the actions of …

Schizophrenia,“just the facts”: what we know in 2008: part 1: overview

R Tandon, MS Keshavan, HA Nasrallah - Schizophrenia research, 2008 - Elsevier
For every disorder, there is a set of established findings and accepted constructs upon which
further understanding is built. The concept of schizophrenia as a disease entity has been …

Meta-analysis of the P300 and P50 waveforms in schizophrenia

E Bramon, S Rabe-Hesketh, P Sham, RM Murray… - Schizophrenia …, 2004 - Elsevier
Objective: To determine whether patients with schizophrenia have abnormalities in the P300
and P50 waves and to quantify the magnitude of any differences from controls. Method: We …

Schizophrenia: the broken P300 and beyond

JM Ford - Psychophysiology, 1999 - cambridge.org
Many of the social, economic, and political problems facing people with schizophrenia are
due to a misconception in the community that schizophrenia is not a biologically based …

Neurophysiological biomarkers for drug development in schizophrenia

DC Javitt, KM Spencer, GK Thaker, G Winterer… - Nature Reviews Drug …, 2008 - nature.com
Schizophrenia represents a pervasive deficit in brain function, leading to hallucinations and
delusions, social withdrawal and a decline in cognitive performance. As the underlying …

Trait and state aspects of P300 amplitude reduction in schizophrenia: a retrospective longitudinal study

DH Mathalon, JM Ford, A Pfefferbaum - Biological psychiatry, 2000 - Elsevier
Background: The P300 component of the auditory event-related brain potential (ERP) is
consistently reduced in schizophrenia. Longitudinal data are examined to determine …

Reduced auditory evoked potential component N100 in schizophrenia—a critical review

T Rosburg, NN Boutros, JM Ford - Psychiatry research, 2008 - Elsevier
The role of a reduced N100 (or N1) component of the auditory event related potential as a
potential trait marker of schizophrenia is critically discussed in this review. We suggest that …

Is the P300 wave an endophenotype for schizophrenia? A meta-analysis and a family study

E Bramon, C McDonald, RJ Croft, S Landau, F Filbey… - Neuroimage, 2005 - Elsevier
INTRODUCTION:: We assessed the usefulness of the P300 wave as endophenotype for
schizophrenia by means of a meta-analysis of the literature as well as our own family study …

Heritability and reliability of P300, P50 and duration mismatch negativity

MH Hall, K Schulze, F Rijsdijk, M Picchioni, U Ettinger… - Behavior genetics, 2006 - Springer
Abstract Background Event-related potentials (ERPs) have been suggested as possible
endophenotypes of schizophrenia. We investigated the test–retest reliabilities and …

Association between BDNF val66 met genotype and episodic memory

E Dempster, T Toulopoulou… - American Journal of …, 2005 - Wiley Online Library
The val66 met polymorphism of brain derived neurotrophic factor (BDNF) has been
associated with variability in episodic memory [Egan et al., 2003]. In an attempt to replicate …