Self-assembly as a key player for materials nanoarchitectonics

K Ariga, M Nishikawa, T Mori, J Takeya… - … and Technology of …, 2019 - Taylor & Francis
The development of science and technology of advanced materials using nanoscale units
can be conducted by a novel concept involving combination of nanotechnology …

Delivery of drugs, proteins, and nucleic acids using inorganic nanoparticles

DC Luther, R Huang, T Jeon, X Zhang, YW Lee… - Advanced drug delivery …, 2020 - Elsevier
Inorganic nanoparticles provide multipurpose platforms for a broad range of delivery
applications. Intrinsic nanoscopic properties provide access to unique magnetic and optical …

Direct cytosolic delivery of CRISPR/Cas9-ribonucleoprotein for efficient gene editing

R Mout, M Ray, G Yesilbag Tonga, YW Lee, T Tay… - ACS …, 2017 - ACS Publications
Genome editing through the delivery of CRISPR/Cas9-ribonucleoprotein (Cas9-RNP)
reduces unwanted gene targeting and avoids integrational mutagenesis that can occur …

Polymers for cytosolic protein delivery

J Lv, Q Fan, H Wang, Y Cheng - Biomaterials, 2019 - Elsevier
Cytosolic protein delivery offers opportunities to develop protein-based therapeutics
specifically modulate intracellular processes, especially those linked to 'undruggable'targets …

Tailoring Hyperbranched Poly (β‐amino ester) as a Robust and Universal Platform for Cytosolic Protein Delivery

X Liu, Z Zhao, F Wu, Y Chen, L Yin - Advanced Materials, 2022 - Wiley Online Library
Cytosolic protein delivery is a prerequisite for protein‐based biotechnologies and
therapeutics on intracellular targets. Polymers that can complex with proteins to form nano …

Multicomponent self-assembly as a tool to harness new properties from peptides and proteins in material design

BO Okesola, A Mata - Chemical Society Reviews, 2018 - pubs.rsc.org
Nature is enriched with a wide variety of complex, synergistic, and highly functional protein-
based multicomponent assemblies. As such, nature has served as a source of inspiration for …

Dynamic polymer amphiphiles for efficient intracellular and in vivo protein delivery

J Xu, Z Li, Q Fan, J Lv, Y Li, Y Cheng - Advanced Materials, 2021 - Wiley Online Library
Intracellular delivery of proteins is receiving considerable attention in biotherapeutics for
various diseases by replacing dysfunctional proteins. Successful intracellular protein …

Protein delivery into cells using inorganic nanoparticle–protein supramolecular assemblies

F Scaletti, J Hardie, YW Lee, DC Luther… - Chemical Society …, 2018 - pubs.rsc.org
The delivery of proteins into cells is a potential game changer for a wide array of therapeutic
purposes, including cancer therapy, immunomodulation and treatment of inherited diseases …

General Strategy for Direct Cytosolic Protein Delivery via Protein–Nanoparticle Co-engineering

R Mout, M Ray, T Tay, K Sasaki, G Yesilbag Tonga… - ACS …, 2017 - ACS Publications
Endosomal entrapment is a key hurdle for most intracellular protein-based therapeutic
strategies. We report a general strategy for efficient delivery of proteins to the cytosol through …

[HTML][HTML] Protein delivery into the cell cytosol using non-viral nanocarriers

YW Lee, DC Luther, JA Kretzmann, A Burden… - Theranostics, 2019 - ncbi.nlm.nih.gov
Protein delivery into cells is a potentially transformative tool for treating “undruggable”
targets in diseases associated with protein deficiencies or mutations. The vast majority of …