Therapeutic drug monitoring (TDM) receives growing interest in different psychiatric clinical
settings (emergency, inpatient, and outpatient services). Despite its usefulness, TDM …

Background For psychotic disorders (ie schizophrenia), pharmacotherapy plays a key role in
controlling acute and long-term symptoms. To find the optimal individual dose and dosage …

Model-informed precision dosing (MIPD) is an advanced quantitative approach focusing on
individualized dosage optimization, integrating complex mathematical and statistical models …

The development of Pharmacogenetics and Pharmacogenomics in Western Europe is
highly relevant in the worldwide scenario. Despite the usually low institutional support, many …

Exploring the possible correlations between gene variations and the clinical effects of the
new-generation antipsychotics is considered essential in the framework of personalized …

Introduction Long-acting injectable (LAI) formulations of second-generation antipsychotics
(SGA) are a mainstay in the treatment of schizophrenia-spectrum patients, and their use …

Definition of an appropriate and personalized treatment plan focused on long-term
outcomes is crucial in the management of schizophrenia. Following review of the literature, a …

Schizophrenia is a complex and chronic psychiatric disorder that significantly impacts
patients' quality of life. Ranking 12th among 310 diseases and injuries that result in …

Purpose: Therapeutic drug monitoring (TDM) is a well-established tool for guiding
psychopharmacotherapy and improving patient care. Despite their established roles in the …

Despite the long and sometimes enthusing history of pharmacological therapy in psychiatry,
the hard truth is that unfortunately a quite large percentage of patients is still not responding …