The bromodomain acts to recognize acetylated lysine in histones and transcription proteins
and plays a fundamental role in chromatin-based cellular processes including gene …

Histone deacetylases (HDACs) catalyze the hydrolysis of acetyl-l-lysine side chains in
histones and non-histones, which are key to epigenetic regulation in humans. Targeting …

Breast cancer is susceptible to Candida infections, and candidiasis has an enhancing effect
on the progression and metastasis of tumor. Breast cancer and concurrent candidiasis …

Over the past several decades, invasive fungal infections, especially candidiasis, have
caused dramatic morbidity and mortality due to ineffective antifungal drugs and severe drug …

Acute lung injury (ALI) and sepsis are both serious and complex conditions associated with
high mortality, yet there are no effective treatments. Herein, we designed and synthesized a …

Bromodomain and extra-terminal domain (BET) proteins and histone deacetylases (HDACs)
are prime targets in cancer therapy. Recent research has particularly focused on the …

Introduction The current drug discovery paradigm of 'one drug, multiple targets' has gained
attention from both the academic medicinal chemistry community and the pharmaceutical …

The activation of the STAT signal after incubation with the HDAC inhibitor represents a key
mechanism causing resistance to HDAC inhibitors in some solid tumor cells, while the FGFR …

Histone deacetylase (HDAC) inhibitors have gained attention over the past three decades
because of their potential in the treatment of different diseases including various forms of …

Histone deacetylases (HDACs) are a class of enzymes that cleave acyl groups from lysine
residues of histone and non-histone proteins. There are 18 human HDAC isoforms with …