Regulation of nutrient transport across the placenta

S Lager, TL Powell - Journal of pregnancy, 2012 - Wiley Online Library
Abnormal fetal growth, both growth restriction and overgrowth, is associated with perinatal
complications and an increased risk of metabolic and cardiovascular disease later in life …

SLC27 fatty acid transport proteins

CM Anderson, A Stahl - Molecular aspects of medicine, 2013 - Elsevier
The uptake and metabolism of long chain fatty acids (LCFA) are critical to many
physiological and cellular processes. Aberrant accumulation or depletion of LCFA underlie …

Acyl-CoA metabolism and partitioning

TJ Grevengoed, EL Klett… - Annual review of …, 2014 - annualreviews.org
Long-chain fatty acyl-coenzyme As (CoAs) are critical regulatory molecules and metabolic
intermediates. The initial step in their synthesis is the activation of fatty acids by one of 13 …

Placental adaptations in growth restriction

S Zhang, TRH Regnault, PL Barker, KJ Botting… - Nutrients, 2015 - mdpi.com
The placenta is the primary interface between the fetus and mother and plays an important
role in maintaining fetal development and growth by facilitating the transfer of substrates and …

Placental function and the development of fetal overgrowth and fetal growth restriction

JH Dumolt, TL Powell… - Obstetrics and Gynecology …, 2021 - obgyn.theclinics.com
The developing fetus undergoes a dynamic period of rapid growth that is responsive to
changes in the in utero environment that may contribute to the development of fetal growth …

Exercise rescues obese mothers' insulin sensitivity, placental hypoxia and male offspring insulin sensitivity

DS Fernandez-Twinn, G Gascoin, B Musial, S Carr… - Scientific reports, 2017 - nature.com
The prevalence of obesity during pregnancy continues to increase at alarming rates. This is
concerning as in addition to immediate impacts on maternal wellbeing, obesity during …

Isolation of human trophoblastic extracellular vesicles and characterization of their cargo and antiviral activity

Y Ouyang, A Bayer, T Chu, VA Tyurin, VE Kagan… - Placenta, 2016 - Elsevier
Introduction Primary human trophoblasts release a repertoire of extracellular vesicles (EVs).
Among them are nano-sized exosomes, which we found to suppress the replication of a …

Maternal obesity modulates intracellular lipid turnover in the human term placenta

B Hirschmugl, G Desoye, P Catalano… - International journal of …, 2017 - nature.com
Background: Obesity before pregnancy is associated with impaired metabolic status of the
mother and the offspring later in life. These adverse effects have been attributed to …

Role of insulin in placental transport of nutrients in gestational diabetes mellitus

M Ruiz-Palacios, AJ Ruiz-Alcaraz… - Annals of Nutrition and …, 2017 - karger.com
Background: Gestational diabetes mellitus (GDM) is associated with increased fetal
adiposity, which may increase the risk of obesity in adulthood. The placenta has insulin …

FATP2-targeted therapies—A role beyond fatty liver disease

P Qiu, H Wang, M Zhang, M Zhang, R Peng… - Pharmacological …, 2020 - Elsevier
Fatty acid transport protein 2 (FATP2) is a multifunctional protein whose specific function is
determined by the type of located cell, its intracellular location, or organelle-specific …