An overview of the immune mechanisms of viral myocarditis

N Lasrado, J Reddy - Reviews in medical virology, 2020 - Wiley Online Library
Viral myocarditis has been identified as a major cause of dilated cardiomyopathy (DCM) that
can lead to heart failure. Historically, Coxsackieviruses and adenoviruses have been …

Guidelines for evaluating myocardial cell death

PK Mishra, A Adameova, JA Hill… - American Journal …, 2019 - journals.physiology.org
Cell death is a fundamental process in cardiac pathologies. Recent studies have revealed
multiple forms of cell death, and several of them have been demonstrated to underlie …

Mitochondrial damage activates the NLRP10 inflammasome

T Próchnicki, MB Vasconcelos, KS Robinson… - Nature …, 2023 - nature.com
Upon detecting pathogens or cell stress, several NOD-like receptors (NLRs) form
inflammasome complexes with the adapter ASC and caspase-1, inducing gasdermin D …

Mitochondrial calpain-1 activates NLRP3 inflammasome by cleaving ATP5A1 and inducing mitochondrial ROS in CVB3-induced myocarditis

X Liu, M Li, Z Chen, Y Yu, H Shi, Y Yu, Y Wang… - Basic Research in …, 2022 - Springer
Abstract Treatment options for myocarditis are currently limited. Inhibition of calpains has
been shown to prevent Coxsackievirus B3 (CVB3)-induced cardiac injuries, but the …

Programmed necrosis in heart disease: molecular mechanisms and clinical implications

H Zhu, A Sun - Journal of molecular and cellular cardiology, 2018 - Elsevier
Programmed cell death plays an essential role in myocardial homeostasis and pathology.
Three distinct forms of programmed cell death have been identified, namely apoptosis …

Clinical and molecular characterization of COVID-19 hospitalized patients

E Benetti, A Giliberti, A Emiliozzi, F Valentino… - Plos one, 2020 - journals.plos.org
Clinical and molecular characterization by Whole Exome Sequencing (WES) is reported in
35 COVID-19 patients attending the University Hospital in Siena, Italy, from April 7 to May 7 …

Drug repositioning for hand, foot, and mouth disease

R Yan, J He, G Liu, J Zhong, J Xu, K Zheng, Z Ren… - Viruses, 2022 - mdpi.com
Hand, foot, and mouth disease (HFMD) is a highly contagious disease in children caused by
a group of enteroviruses. HFMD currently presents a major threat to infants and young …

Repeated generalized seizures can produce calcified cardiac lesions in DBA/1 mice

H Zhao, H Zhang, FJ Schoen, SC Schachter… - Epilepsy & Behavior, 2019 - Elsevier
Studies suggest that cardiorespiratory dysfunction likely contributes to sudden unexpected
death in epilepsy (SUDEP). Seizures result in autonomic and respiratory dysfunction …

Viral myocarditis: from molecular mechanisms to therapeutic prospects

HW Yan, YD Feng, N Tang, FC Cao, YF Lei… - European Journal of …, 2024 - Elsevier
Myocarditis is characterized as local or diffuse inflammatory lesions in the myocardium,
primarily caused by viruses and other infections. It is a common cause of sudden cardiac …

Mt10 Vaccine Protects Diversity Outbred Mice from CVB3 Infection by Producing Virus-Specific Neutralizing Antibodies and Diverse Antibody Isotypes

MT Rasquinha, K Mone, M Sur, N Lasrado… - Vaccines, 2024 - mdpi.com
Group B coxsackieviruses (CVBs) cause a wide range of diseases in humans, but no
vaccines are currently available to prevent these infections. Previously, we had …