Axon guidance molecules direct growing axons toward their targets, assembling the intricate
wiring of the nervous system. One of these molecules, Netrin-1, and its receptor, DCC …

The development of a functional nervous system entails establishing connectivity between
appropriate synaptic partners. During axonal pathfinding, the developing axon navigates …

The numbers and strengths of synapses in the brain change throughout development, and
even into adulthood, as synaptic inputs are added, eliminated, and refined in response to …

The molecular code that controls synapse formation and maintenance in vivo has remained
quite sparse. Here, we identify that the secreted protein Adamtsl3 functions as critical …

Chronic pain is often present at more than one anatomical location, leading to chronic
overlapping pain conditions. Whether chronic overlapping pain conditions represent a …

The Netrin-1/DCC guidance cue pathway plays a critical role in guiding growing axons
toward the prefrontal cortex during adolescence and in the maturational organization and …

Schizophrenia (SZ) is a complex neuropsychiatric disorder, affecting 1% of the world
population. Long-standing clinical observations and molecular data have pointed to a …

Adult neural plasticity engages mechanisms that change synapse structure and function, yet
many of the underlying events bear a striking similarity to processes that occur during the …

Presynaptic kainate (KA) receptors (KARs) modulate GABA and glutamate release in the
central nervous system of mammals. While some of the actions of KARs are ionotropic …

The axonal guidance cue netrin-1 serves a critical role in neural circuit development by
promoting growth cone motility, axonal branching, and synaptogenesis. Within the adult …