Structural biologists have traditionally approached cellular complexity in a reductionist
manner in which the cellular molecular components are fractionated and purified before …

Classical nucleation and crystal growth theories describe how nuclei form, become stable
after reaching a critical size and then enlarge through monomer attachment. More than two …

Protein complexes of the mitochondrial respiratory chain assemble into respiratory
supercomplexes. Here we present the high-resolution electron cryo-microscopy structure of …

Cryo-electron microscopy (cryo-EM) is rapidly becoming an attractive method in the field of
structural biology. With the exploding popularity of cryo-EM, sample preparation must evolve …

Jetting-based bioprinting facilitates contactless drop-on-demand deposition of subnanoliter
droplets at well-defined positions to control the spatial arrangement of cells, growth factors …

We seek to completely revise current models of airborne transmission of respiratory viruses
by providing never-before-seen atomic-level views of the SARS-CoV-2 virus within a …

All steps of cryogenic electron-microscopy (cryo-EM) workflows have rapidly evolved over
the last decade. Advances in both single-particle analysis (SPA) cryo-EM and cryo-electron …

The increasing demand for cryo-electron microscopy (cryo-EM) reveals drawbacks in current
sample preparation protocols, such as sample waste and lack of reproducibility. Here, we …

Most information loss in cryogenic electron microscopy (cryo-EM) stems from particle
movement during imaging, which remains poorly understood. We show that this movement …

Reconstruction maps of cryo–electron microscopy (cryo-EM) exhibit distortion when the cryo-
EM dataset is incomplete, usually caused by unevenly distributed orientations. Prior efforts …