Exploring the expanding universe of small RNAs
The world of small noncoding RNAs (sncRNAs) is ever-expanding, from small interfering
RNA, microRNA and Piwi-interacting RNA to the recently emerging non-canonical sncRNAs …
RNA, microRNA and Piwi-interacting RNA to the recently emerging non-canonical sncRNAs …
tRNA-derived small RNA: a novel regulatory small non-coding RNA
S Li, Z Xu, J Sheng - Genes, 2018 - mdpi.com
Deep analysis of next-generation sequencing data unveils numerous small non-coding
RNAs with distinct functions. Recently, fragments derived from tRNA, named as tRNA …
RNAs with distinct functions. Recently, fragments derived from tRNA, named as tRNA …
Meta-analysis of tRNA derived RNA fragments reveals that they are evolutionarily conserved and associate with AGO proteins to recognize specific RNA targets
Background tRFs, 14 to 32 nt long single-stranded RNA derived from mature or precursor
tRNAs, are a recently discovered class of small RNA that have been found to be present in …
tRNAs, are a recently discovered class of small RNA that have been found to be present in …
Stem cell function and stress response are controlled by protein synthesis
Whether protein synthesis and cellular stress response pathways interact to control stem cell
function is currently unknown. Here we show that mouse skin stem cells synthesize less …
function is currently unknown. Here we show that mouse skin stem cells synthesize less …
Aberrant methylation of t RNA s links cellular stress to neuro‐developmental disorders
S Blanco, S Dietmann, JV Flores, S Hussain… - The EMBO …, 2014 - embopress.org
Mutations in the cytosine‐5 RNA methyltransferase NSun2 cause microcephaly and other
neurological abnormalities in mice and human. How post‐transcriptional methylation …
neurological abnormalities in mice and human. How post‐transcriptional methylation …
Biogenesis and function of transfer RNA-related fragments (tRFs)
Noncoding small RNAs arise from the various un-annotated and annotated regions of the
genome. When they arise from annotated genes, the noncoding small RNAs are functionally …
genome. When they arise from annotated genes, the noncoding small RNAs are functionally …
[HTML][HTML] tRNA fragments in human health and disease
P Anderson, P Ivanov - FEBS letters, 2014 - Elsevier
Transfer RNA (tRNA) is traditionally considered to be an adaptor molecule that helps
ribosomes to decode messenger RNA (mRNA) and synthesize protein. Recent studies have …
ribosomes to decode messenger RNA (mRNA) and synthesize protein. Recent studies have …
tRNAs as regulators of biological processes
Transfer RNAs (tRNA) are best known for their role as adaptors during translation of the
genetic code. Beyond their canonical role during protein biosynthesis, tRNAs also perform …
genetic code. Beyond their canonical role during protein biosynthesis, tRNAs also perform …
The presence, role and clinical use of spermatozoal RNAs
M Jodar, S Selvaraju, E Sendler… - Human reproduction …, 2013 - academic.oup.com
BACKGROUND Spermatozoa are highly differentiated, transcriptionally inert cells
characterized by a compact nucleus with minimal cytoplasm. Nevertheless they contain a …
characterized by a compact nucleus with minimal cytoplasm. Nevertheless they contain a …
tRNA renovatio: rebirth through fragmentation
B Kuhle, Q Chen, P Schimmel - Molecular Cell, 2023 - cell.com
Summary tRNA function is based on unique structures that enable mRNA decoding using
anticodon trinucleotides. These structures interact with specific aminoacyl-tRNA synthetases …
anticodon trinucleotides. These structures interact with specific aminoacyl-tRNA synthetases …