Brain-derived neurotrophic factor (BDNF) is one of the most distributed and extensively
studied neurotrophins in the mammalian brain. BDNF signals through the tropomycin …

The number of the elderly across the globe will approximate 2.1 billion by 2050. Juxtaposed
against this burgeoning segment of the population is evidence that nonpathological aging is …

Brain-derived neurotrophic factor (BDNF) plays an important role in neuronal survival and
growth, serves as a neurotransmitter modulator, and participates in neuronal plasticity …

GABA is the major inhibitory neurotransmitter that counterbalances excitation in the mature
brain. The inhibitory action of GABA relies on the inflow of chloride ions (Cl−), which …

The potency of the environment to shape brain function changes dramatically across the
lifespan. Neural circuits exhibit profound plasticity during early life and are later stabilized. A …

▪ Abstract Neurotrophins regulate development, maintenance, and function of vertebrate
nervous systems. Neurotrophins activate two different classes of receptors, the Trk family of …

Neuronal circuits in the brain are shaped by experience during'critical periods' in early
postnatal life. In the primary visual cortex, this activity-dependent development is triggered …

Neurotrophic factors, particularly brain-derived neurotrophic factor (BDNF) and other
members of the neurotrophin family, are central mediators of the activity-dependent plasticity …

Vision is critical for the functional and structural maturation of connections in the mammalian
visual system. Visual experience, however, is a subset of a more general requirement for …

Nerve growth factor (NGF) was discovered in the early 1950s due to its trophic (survival-and
growth-promoting) effects on sensory and sympathetic neurons (Levi-Montalcini and …