Synaptic memory and CaMKII

RA Nicoll, H Schulman - Physiological reviews, 2023 - journals.physiology.org
Ca2+/calmodulin-dependent protein kinase II (CaMKII) and long-term potentiation (LTP)
were discovered within a decade of each other and have been inextricably intertwined ever …

Understanding the pathogenetic mechanisms underlying altered neuronal function associated with CAMK2B mutations

R Borghi, M Trivisano, N Specchio, M Tartaglia… - Neuroscience & …, 2023 - Elsevier
Abstract 'Dominant mutations in CAMK2B, encoding a subunit of the calcium/calmodulin-
dependent protein kinase II (CAMK2), a serine/threonine kinase playing a key role in …

Role of CAMK2D in neurodevelopment and associated conditions

PMF Rigter, C de Konink, MJ Dunn, MP Onori… - The American Journal of …, 2024 - cell.com
The calcium/calmodulin-dependent protein kinase type 2 (CAMK2) family consists of four
different isozymes, encoded by four different genes—CAMK2A, CAMK2B, CAMK2G, and …

CAMK2-dependent signaling in neurons is essential for survival

MJ Kool, MP Onori, NZ Borgesius… - Journal of …, 2019 - Soc Neuroscience
Ca2+/calmodulin-dependent protein kinase II (CAMK2) is a key player in synaptic plasticity
and memory formation. Mutations in Camk2a or Camk2b cause intellectual disability in …

TAOK1 is associated with neurodevelopmental disorder and essential for neuronal maturation and cortical development

GM van Woerden, M Bos, C de Konink… - Human …, 2021 - Wiley Online Library
Thousand and one amino‐acid kinase 1 (TAOK1) is a MAP3K protein kinase, regulating
different mitogen‐activated protein kinase pathways, thereby modulating a multitude of …

A loss of function variant in AGPAT3 underlies intellectual disability and retinitis pigmentosa (IDRP) syndrome

MA Malik, MAN Saqib, E Mientjes, A Acharya… - European Journal of …, 2023 - nature.com
Intellectual disability (ID) and retinal dystrophy (RD) are the frequently found features of
multiple syndromes involving additional systemic manifestations. Here, we studied a family …

Neuronal L-type calcium channel signaling to the nucleus requires a novel CaMKIIα-Shank3 interaction

TL Perfitt, X Wang, MT Dickerson… - Journal of …, 2020 - Soc Neuroscience
The activation of neuronal plasma membrane Ca2+ channels stimulates many intracellular
responses. Scaffolding proteins can preferentially couple specific Ca2+ channels to distinct …

Role of Ca2+/Calmodulin-Dependent Protein Kinase Type II in Mediating Function and Dysfunction at Glutamatergic Synapses

AG Mohanan, S Gunasekaran, RS Jacob… - Frontiers in molecular …, 2022 - frontiersin.org
Glutamatergic synapses harbor abundant amounts of the multifunctional Ca2+/calmodulin-
dependent protein kinase type II (CaMKII). Both in the postsynaptic density as well as in the …

The response of glandular gastric transcriptome to T-2 toxin in chicks

JJ Luo, Y Zhang, H Sun, JT Wei, MM Khalil… - Food and Chemical …, 2019 - Elsevier
This study was conducted to determine the effect of T-2 toxin on the transcriptome of the
glandular stomach in chicks using RNA-sequencing (RNA-Seq). Four groups of 1-day-old …

CaMKII controls neuromodulation via neuropeptide gene expression and axonal targeting of neuropeptide vesicles

A Moro, GM Van Woerden, RF Toonen… - PLoS biology, 2020 - journals.plos.org
Ca2+/calmodulin-dependent kinase II (CaMKII) regulates synaptic plasticity in multiple ways,
supposedly including the secretion of neuromodulators like brain-derived neurotrophic …