The prefrontal cortex, pathological anxiety, and anxiety disorders

MM Kenwood, NH Kalin, H Barbas - Neuropsychopharmacology, 2022 - nature.com
Anxiety is experienced in response to threats that are distal or uncertain, involving changes
in one's subjective state, autonomic responses, and behavior. Defensive and physiologic …

The Structural Model: a theory linking connections, plasticity, pathology, development and evolution of the cerebral cortex

MÁ García-Cabezas, B Zikopoulos… - Brain Structure and …, 2019 - Springer
The classical theory of cortical systematic variation has been independently described in
reptiles, monotremes, marsupials and placental mammals, including primates, suggesting a …

The tie that binds: temporal coding and adaptive emotion

J Wang, A Tambini, RC Lapate - Trends in Cognitive Sciences, 2022 - cell.com
Emotions are temporally dynamic, but the persistence of emotions outside of their
appropriate temporal context is detrimental to health and well-being. Yet, precisely how …

Thalamocortical mechanisms regulating the relationship between transient beta events and human tactile perception

RG Law, S Pugliese, H Shin, DD Sliva, S Lee… - Cerebral …, 2022 - academic.oup.com
Transient neocortical events with high spectral power in the 15–29 Hz beta band are among
the most reliable predictors of sensory perception. Prestimulus beta event rates in primary …

Timescales of learning in prefrontal cortex

JA Miller, C Constantinidis - Nature Reviews Neuroscience, 2024 - nature.com
The lateral prefrontal cortex (PFC) in humans and other primates is critical for immediate,
goal-directed behaviour and working memory, which are classically considered distinct from …

Pathways for contextual memory: the primate hippocampal pathway to anterior cingulate cortex

J Wang, Y John, H Barbas - Cerebral cortex, 2021 - academic.oup.com
The anterior cingulate cortex (ACC) is one of the few prefrontal areas that receives robust
direct hippocampal terminations. This pathway may enable current context and past …

Cytoarchitectonic gradients of laminar degeneration in behavioural variant frontotemporal dementia

DT Ohm, SX Xie, N Capp, S Arezoumandan… - Brain, 2025 - academic.oup.com
Behavioural variant frontotemporal dementia (bvFTD) is a clinical syndrome caused
primarily by either tau (bvFTD-tau) or transactive response DNA-binding protein of 43 kDa …

Serial prefrontal pathways are positioned to balance cognition and emotion in primates

MKP Joyce, MÁ García-Cabezas, YJ John… - Journal of …, 2020 - Soc Neuroscience
The delicate balance among primate prefrontal networks is necessary for homeostasis and
behavioral flexibility. Dorsolateral prefrontal cortex (dlPFC) is associated with cognition …

Explicit instruction and executive functioning capacity: A new direction in cognitive load theory

NR Siregar - Journal of Education, 2023 - journals.sagepub.com
Explicit instruction is a teaching strategy that aims to avoid cognitive overload experienced
by students which aims to improve academic performance. Previous research has …

Cortical type: a conceptual tool for meaningful biological interpretation of high-throughput gene expression data in the human cerebral cortex

A Sancha-Velasco, A Uceda-Heras… - Frontiers in …, 2023 - frontiersin.org
The interpretation of massive high-throughput gene expression data requires computational
and biological analyses to identify statistically and biologically significant differences …