Regulation of emt markers, extracellular matrix, and associated signalling pathways by long non-coding rnas in glioblastoma mesenchymal transition: a scoping …

DHL Leung, BWS Phon, M Sivalingam… - Biology, 2023 - mdpi.com
Simple Summary Glioblastoma (GBM) is the most lethal type of brain tumour due to the high
invasiveness caused by the process of mesenchymal (MES) transition. This process is …

Biomaterial-based in vitro 3D modeling of glioblastoma multiforme

T Ahmed - Cancer Pathogenesis and Therapy, 2023 - mednexus.org
Adult-onset brain cancers, such as glioblastomas, are particularly lethal. People with
glioblastoma multiforme (GBM) do not anticipate living for more than 15 months if there is no …

[HTML][HTML] Revisiting ABC Transporters and Their Clinical Significance in Glioblastoma

BWS Phon, SS Chelliah, DER Osman… - Pharmaceuticals, 2025 - mdpi.com
Background: The multiple drug-resistant phenomenon has long since plagued the
effectiveness of various chemotherapies used in the treatment of patients with glioblastoma …

Hydrogel arrays enable increased throughput for screening effects of matrix components and therapeutics in 3D tumor models

J Liang, A Sohrabi, M Epperson… - Journal of …, 2022 - pmc.ncbi.nlm.nih.gov
Cell-matrix interactions mediate complex physiological processes through biochemical,
mechanical, and geometrical cues, influencing pathological changes and therapeutic …

Identification of Prominent Genes between 3D Glioblastoma Models and Clinical Samples via GEO/TCGA/CGGA Data Analysis

BWS Phon, S Bhuvanendran, Q Ayub… - Biology, 2023 - mdpi.com
Simple Summary Glioblastoma multiforme (GBM) is a deadly brain tumour with little
progression in the way of improved quality of life in patients. The possible root cause for this …

3D cell models in radiobiology: improving the predictive value of in vitro research

F Antonelli - International Journal of Molecular Sciences, 2023 - mdpi.com
Cancer is intrinsically complex, comprising both heterogeneous cellular composition and
extracellular matrix. In vitro cancer research models have been widely used in the past to …

Exploring miRNA therapies and gut microbiome–enhanced CAR-T cells: advancing frontiers in glioblastoma stem cell targeting

K Sandhanam, T Tamilanban, B Bhattacharjee… - Naunyn-Schmiedeberg's …, 2024 - Springer
Glioblastoma multiforme (GBM) presents a formidable challenge in oncology due to its
aggressive nature and resistance to conventional treatments. Recent advancements …

Tissue Engineered Models of Brain Tumors and Their Applications

T Bal - Bioinformatics of the Brain, 2024 - taylorfrancis.com
Whole body is governed by the brain. It monitors and regulates various bodily functions.
Thus, any error or any diversion to the pathological state in the form of brain-based diseases …

Radiopharmaceuticals for molecular imaging and theranostics of glioblastoma

CIG Pinto, JF Guerreiro, F Silva, F Mendes… - New Insights Into …, 2023 - Elsevier
The present chapter provides a comprehensive review of the more relevant contributions of
nuclear modalities and radiopharmaceuticals for the diagnosis, therapy and follow-up of …

Study of the Role of NRF2 in the Progression and Metabolic Adaptation of Glioblastoma

M Moubarak - 2024 - theses.hal.science
Glioblastoma (GB), the most aggressive form of brain tumor, poses substantial therapeutic
challenges due to its invasive behavior, treatment resistance, and genetic heterogeneity …