There is increasing evidence that a variety of cancers arise from transformation of normal
stem cells to cancer stem cells (CSCs). CSCs are thought to sustain cancer progression …

Abstract The transcription factor Yin Yang 1 (YY1) is frequently overexpressed in cancerous
tissues compared to normal tissues and has regulatory roles in cell proliferation, cell …

The epithelial–mesenchymal transition (EMT), one of the main mechanisms underlying
development of cancer metastasis, induces stem-like properties in epithelial cells. Bmi1 is a …

Tumor metastasis involves a series of biological steps during which the tumor cells acquire
the ability to invade surrounding tissues and survive outside the original tumor site. During …

Ferroptosis, characterized by iron accumulation and lipid peroxidation (LPO), can avoid the
intrinsic apoptotic resistance of tumor cells and have been explored for glioblastoma (GBM) …

Chemotherapy has been reported to induce epithelial-mesenchymal transition (EMT) in
tumor cells, which is a critical step in the process of metastasis leading to cancer spreading …

Malignant gliomas are the most common central nervous system tumors and the molecular
mechanism driving their development and recurrence is still largely unknown, limiting the …

N-cadherin has been reported to be upregulated and associated with metastasis and poor
prognosis in prostate cancer patients, however the underlying mechanism still remains …

B-cell-specific Moloney murine leukemia virus integration region 1 (Bmi-1, also known as
RNF51 or PCGF4) is one of the important members of the PcG gene family, and is involved …

Background Many of the current standard therapies employed for the management of
primary malignant brain cancers are largely viewed as palliative, ultimately because these …