The authors identified individual randomized controlled trials from previous meta-analyses
and additional searches, and then performed meta-analyses on cardiovascular disease …

Background Results from observational and genetic epidemiological studies suggest that
lower serum homocysteine levels are associated with lower incidence of cardiovascular …

The recommendations listed in this CPG are, whenever possible, evidence based. An
extensive evidence review was conducted through October 2012, and other selected …

Background Cardiovascular disease, which includes coronary artery disease, stroke and
peripheral vascular disease, is a leading cause of death worldwide. Homocysteine is an …

This is an update of the previous 2018 systematic review and meta-analysis of vitamin and
mineral supplementation on cardiovascular disease outcomes and all-cause mortality. New …

Context Hyperhomocysteinemia is frequently observed in patients with diabetic
nephropathy. B-vitamin therapy (folic acid, vitamin B 6, and vitamin B 12) has been shown to …

Thromboembolic manifestations are relatively frequent in patients with intermediate/severe
hyperhomocysteinemia (> 30 µmol/L) related to inherited disorders and deficiencies in …

Context Previous research evaluating the effects in B-vitamins on the prevention and
treatment of cardiovascular disease (CVD) has substantial limitations and lacks recently …

BACKGROUND: In observational studies, lower serum homocysteine levels are associated
with a lower incidence of cardiovascular disease (CVD). However, individual randomized …

Background: The effectiveness of folic acid supplementation in stroke risk has been
investigated, however, the available results are inconclusive and conflicting. The purpose of …