Quantitative Structure Activity Relationship (QSAR) modeling has been traditionally applied
as an evaluative approach, ie, with the focus on developing retrospective and explanatory …

Importance of the field: PubChem is a public molecular information repository, a scientific
showcase of the National Institutes of Health Roadmap Initiative. The PubChem database …

The abnormal expression of the c-Met tyrosine kinase has been linked to the proliferation of
several human cancer cell lines, including non-small-cell lung cancer (NSCLC). In this …

In data mining, regression analysis is a computational tool that predicts continuous output
variables from a number of independent input variables, by approximating their complex …

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An efficient asymmetric cascade sulfa-Michael/Michael addition reaction catalyzed by a
chiral bifunctional squaramide–tertiary amine catalyst has been developed. This …

Many cancer cells are known to have defects in the apoptosis machinery. Therefore
identification of compounds that can activate or promote apoptosis in cancer cells is an …

Background: Synthesis of organic compounds with specific biological activity or
physicochemical characteristics needs a thorough analysis of the enumerable data set …

This part (part II) is devoted to 6-membered heterocycles that are synthesized from
nitroalkenes as the key substrates. These compounds can be simply accessible to form …

Ball milling is used as a facile, efficient, cheap, and environmentally friendly procedure for
the solvent-free three-component reaction of aromatic aldehydes with malononitrile and …