Obesity and psychological distress

A Steptoe, P Frank - … Transactions of the Royal Society B, 2023 - royalsocietypublishing.org
The relationship between high body weight and mental health has been studied for several
decades. Improvements in the quality of epidemiological, mechanistic and psychological …

[HTML][HTML] Obesity as a causal risk factor for depression: systematic review and meta-analysis of Mendelian randomization studies and implications for population mental …

M Jokela, M Laakasuo - Journal of psychiatric research, 2023 - Elsevier
Background/objectives Obesity has been associated with elevated risk of depression. If this
association is causal, the increasing obesity prevalence might lead to worsening population …

Bidirectional two-sample Mendelian randomization analysis identifies causal associations between relative carbohydrate intake and depression

S Yao, M Zhang, SS Dong, JH Wang, K Zhang… - Nature human …, 2022 - nature.com
Growing evidence suggests that relative carbohydrate intake affects depression; however,
the association between carbohydrates and depression remains controversial. To test this …

Evaluating the distinct effects of body mass index at childhood and adulthood on adult major psychiatric disorders

P Xiao, C Li, J Mi, J Wu - Science Advances, 2024 - science.org
Children with high body mass index (BMI) are at heightened risk of developing health issues
in adulthood, yet the causality between childhood BMI and adult psychiatric disorders …

Causal association between obesity, circulating glutamine levels, and depression: a Mendelian randomization study

R He, R Zheng, J Zheng, M Li, T Wang… - The Journal of …, 2023 - academic.oup.com
Context Observational studies indicated obesity and glutamatergic dysfunction as potential
risk factors of depression, and reported disturbance of glutamine metabolism in obese state …

[HTML][HTML] Body mass index and clinical outcomes in individuals with major depressive disorder: Findings from the GSRD European Multicenter Database

C Kraus, A Kautzky, V Watzal, A Gramser… - Journal of affective …, 2023 - Elsevier
Background Individuals with major depressive disorder (MDD) are at higher risk for obesity.
In turn, weight gain is a predisposing factor for depression. Although clinical data are sparse …

Polygenic risk for immuno-metabolic markers and specific depressive symptoms: A multi-sample network analysis study

N Kappelmann, D Czamara, N Rost, S Moser… - Brain, Behavior, and …, 2021 - Elsevier
Background About every fourth patient with major depressive disorder (MDD) shows
evidence of systemic inflammation. Previous studies have shown inflammation-depression …

Body Mass Index and risk for onset of mood and anxiety disorders in the general population: Results from the Netherlands Mental Health Survey and Incidence Study …

L de Wit, M Have, P Cuijpers, R de Graaf - BMC psychiatry, 2022 - Springer
Background Examine the onset of a clinical diagnosis of mood (major depression, dysthymia
and bipolar disorder)-and anxiety disorders (panic disorder, agoraphobia without panic …

[HTML][HTML] The relationship of food addiction with binge eating disorder and obesity: a network analysis study

EA Carbone, M Aloi, M Rania, R de Filippis, D Quirino… - Appetite, 2023 - Elsevier
Food addiction (FA) has been associated with binge eating disorder (BED) and obesity at
varying levels of severity and treatment outcomes. Despite much debate and scientific …

Metabolomics signatures of depression: the role of symptom profiles

H de Kluiver, R Jansen, BWJH Penninx… - Translational …, 2023 - nature.com
Depression shows a metabolomic signature overlapping with that of cardiometabolic
conditions. Whether this signature is linked to specific depression profiles remains …