The zebrafish is an invaluable model organism for genetic, developmental, and disease
research. Although its high conservation with humans is often cited as justification for its use …

Rationale: Loss-of-function of the cardiac sodium channel NaV1. 5 causes conduction
slowing and arrhythmias. NaV1. 5 is differentially distributed within subcellular domains of …

Vertebrate organs develop through a complex process which involves interaction between
multiple signaling pathways at the molecular, cell, and tissue levels. Heart development is …

Abstract miRNAs modulate cardiomyocyte specification by targeting mRNAs of cell cycle
regulators and acting in cardiac muscle lineage gene regulatory loops. It is unknown if or to …

Modularity and hierarchy are important theoretical concepts in biology, and both are useful
frameworks to understand the evolution of complex systems. Gene regulatory networks …

Abstract Bcl9 and Pygopus (Pygo) are obligate Wnt/β-catenin cofactors in Drosophila, yet
their contribution to Wnt signaling during vertebrate development remains unresolved …

Organogenesis involves dynamic regulation of gene transcription and complex
multipathway interactions. Despite our knowledge of key factors regulating various steps of …

Congenital heart defects (CHD) are structural malformations found at birth with a prevalence
of 1%. The clinical trajectory of CHD is highly variable and thus in need of robust diagnostics …

CRISPR-Cas9 sgRNA libraries have transformed functional genetic screening and have
enabled several innovative methods that rely on simultaneously targeting numerous genetic …

Abstract The Polycomb group (PcG) protein family is a well-known group of epigenetic
modifiers. We used zebrafish to investigate the role of Rnf2, the enzymatic subunit of PRC1 …