Rec8 cohesin: a structural platform for shaping the meiotic chromosomes

T Sakuno, Y Hiraoka - Genes, 2022 - mdpi.com
Meiosis is critically different from mitosis in that during meiosis, pairing and segregation of
homologous chromosomes occur. During meiosis, the morphology of sister chromatids …

Meiotic cohesin and variants associated with human reproductive aging and disease

R Beverley, ML Snook… - Frontiers in cell and …, 2021 - frontiersin.org
Successful human reproduction relies on the well-orchestrated development of competent
gametes through the process of meiosis. The loading of cohesin, a multi-protein complex, is …

Disruption of REC8 in Meiosis I led to watermelon seedless

L Cao, C Li, H Li, Z Wang, Y Jiang, Y Guo, P Sun… - Plant Science, 2022 - Elsevier
In triploid watermelon (Citrullus lanatus), the homologous chromosomes of germ cells are
disorder during meiosis, resulting in the failure of seeds formation and producing seedless …

Rec8 Cohesin-mediated Axis-loop chromatin architecture is required for meiotic recombination

T Sakuno, S Tashiro, H Tanizawa… - Nucleic acids …, 2022 - academic.oup.com
During meiotic prophase, cohesin-dependent axial structures are formed in the
synaptonemal complex (SC). However, the functional correlation between these structures …

Kinase PLK1 regulates the disassembly of the lateral elements and the assembly of the inner centromere during the diakinesis/metaphase I transition in male mouse …

R Gómez, A Viera, T Moreno-Mármol… - Frontiers in cell and …, 2023 - frontiersin.org
PLK1 is a serine/threonine kinase with crucial roles during mitosis. However, its involvement
during mammalian male meiosis remains largely unexplored. By inhibiting the kinase …

Non-essential kinetochore proteins contribute to meiotic chromosome condensation through polo-like kinase

D Trakroo, P Agarwal, A Alekar… - Molecular Biology of the …, 2025 - molbiolcell.org
Chromosome condensation plays a pivotal role during faithful chromosome segregation,
hence, understanding the factors that drive condensation is crucial to get mechanistic insight …

DNA double‐strand breaks regulate the cleavage‐independent release of Rec8‐cohesin during yeast meiosis

G Fajish, K Challa, S Salim, A Vp, S Mwaniki… - Genes to …, 2024 - Wiley Online Library
The mitotic cohesin complex necessary for sister chromatid cohesion and chromatin loop
formation shows local and global association to chromosomes in response to DNA double …

Multiple 9-1-1 complexes promote homolog synapsis, DSB repair, and ATR signaling during mammalian meiosis

C Pereira, GA Arroyo-Martinez, MZ Guo, MS Downey… - Elife, 2022 - elifesciences.org
DNA damage response mechanisms have meiotic roles that ensure successful gamete
formation. While completion of meiotic double-strand break (DSB) repair requires the …

Meiotic sex chromosome cohesion and autosomal synapsis are supported by Esco2

F McNicoll, A Kühnel, U Biswas… - Life Science …, 2020 - life-science-alliance.org
In mitotic cells, establishment of sister chromatid cohesion requires acetylation of the
cohesin subunit SMC3 (acSMC3) by ESCO1 and/or ESCO2. Meiotic cohesin plays …

Higher meiotic chromosome condensation: a potential function of kinetochore through polo-like kinase

D Trakroo, P Agarwal, A Alekar, SK Ghosh - bioRxiv, 2023 - biorxiv.org
Chromosome condensation plays a pivotal role during faithful chromosome segregation,
hence understanding the factors that drive condensation is crucial to get mechanistic insight …