A large proportion of patients with chronic kidney disease (CKD) are vitamin D deficient
(plasma 25-hydroxyvitamin D (25 (OH) D)< 25 or 30 nmol/L per UK and US population …

Simple Summary Anti-cancer treatments induced an increase in the childhood cancer
survival rate. However, they are responsible for several long-term side effects in childhood …

Vitamin D deficiency is associated with a range of muscle disorders, including myalgia,
muscle weakness, and falls. In humans, polymorphisms of the vitamin D receptor (VDR) …

Despite its rigid structure, the bone is a dynamic organ, and is highly regulated by endocrine
factors. One of the major bone regulatory hormones is vitamin D. Its renal metabolite 1α, 25 …

Bone formation is indirectly influenced by 1, 25-dihydroxyvitamin D3 (1, 25D3) through the
stimulation of calcium uptake in the intestine and re-absorption in the kidneys. Direct effects …

Vitamin D is a micronutrient with pleiotropic effects in humans. Due to sedentary lifestyles
and increasing time spent indoors, a growing body of research is revealing that vitamin D …

At the early stage of chronic kidney disease (CKD), the systemic mineral metabolism and
bone composition start to change. This alteration is known as chronic kidney disease …

The interaction between vitamin D and osteoblasts is complex. In the current review we will
give an overview of the current knowledge of the vitamin D endocrine system in osteoblasts …

Beyond the established roles of vitamin D in bone and mineral homeostasis, we are
becoming increasingly aware of its diverse effects in skeletal muscle. Subjects with severe …

Beyond the established effects of muscle loading on bone, a complex network of hormones
and growth factors integrates these adjacent tissues. One such hormone, vitamin D, exerts …