HDL function and atherosclerosis: reactive dicarbonyls as promising targets of therapy
MRF Linton, PG Yancey, H Tao, SS Davies - Circulation research, 2023 - Am Heart Assoc
Epidemiologic studies detected an inverse relationship between HDL (high-density
lipoprotein) cholesterol (HDL-C) levels and atherosclerotic cardiovascular disease …
lipoprotein) cholesterol (HDL-C) levels and atherosclerotic cardiovascular disease …
Macrophage and T cell networks in adipose tissue
RD Jacks, CN Lumeng - Nature Reviews Endocrinology, 2024 - nature.com
The signals and structure of the tissues in which leukocytes reside critically mould leukocyte
function and development and have challenged our fundamental understanding of how to …
function and development and have challenged our fundamental understanding of how to …
IsoLGs (Isolevuglandins) drive neutrophil migration in hypertension and are essential for the formation of neutrophil extracellular traps
Background: IsoLGs (isolevuglandins) are electrophilic products of lipid peroxidation formed
in the presence of reactive oxygen species. IsoLGs contribute to hypertension by an …
in the presence of reactive oxygen species. IsoLGs contribute to hypertension by an …
Role of Axl in target organ inflammation and damage due to hypertensive aortic remodeling
W Chen, JP Van Beusecum, L Xiao… - American Journal …, 2022 - journals.physiology.org
We have shown that excessive endothelial cell stretch causes release of growth arrest-
specific 6 (GAS6), which activates the tyrosine kinase receptor Axl on monocytes and …
specific 6 (GAS6), which activates the tyrosine kinase receptor Axl on monocytes and …
Immunometabolic alterations in lupus: where do they come from and where do we go from there?
Highlights•Immunometabolism dysregulations in lupus have multifactorial
origins.•Contributing factors include genetics and chronic autoantigen stimulation.• …
origins.•Contributing factors include genetics and chronic autoantigen stimulation.• …
NETosis Drives Blood Pressure Elevation and Vascular Dysfunction in Hypertension
BACKGROUND: Neutrophil extracellular traps (NETs) are composed of DNA, enzymes, and
citrullinated histones that are expelled by neutrophils in the process of NETosis. NETs …
citrullinated histones that are expelled by neutrophils in the process of NETosis. NETs …
Immunoproteasomal Processing of IsoLG-Adducted Proteins Is Essential for Hypertension
N de la Visitación, W Chen, J Krishnan… - Circulation …, 2024 - Am Heart Assoc
BACKGROUND: Hypertension is characterized by CD8+ (cluster differentiation 8) T cell
activation and infiltration into peripheral tissues. CD8+ T cell activation requires proteasomal …
activation and infiltration into peripheral tissues. CD8+ T cell activation requires proteasomal …
Pathological mechanisms of cigarette smoking, dietary, and sedentary lifestyle risks in vascular dysfunction: mitochondria as a common target of risk factors
SI Dikalov, S Gutor, AE Dikalova - Pflügers Archiv-European Journal of …, 2023 - Springer
In the past century, the lifespan of the human population has dramatically increased to the
80 s, but it is hindered by a limited health span to the 60 s due to an epidemic increase in the …
80 s, but it is hindered by a limited health span to the 60 s due to an epidemic increase in the …
[HTML][HTML] The impact of increasing levels of blood C-reactive protein on the inflammatory loci SPI1 and CD33 in Alzheimer's disease
Abstract Apolipoprotein ε4 (APOE ε4) is the most significant genetic risk factor for late-onset
Alzheimer's disease (AD). Elevated blood C-reactive protein (CRP) further increases the risk …
Alzheimer's disease (AD). Elevated blood C-reactive protein (CRP) further increases the risk …
[HTML][HTML] The nutraceutical electrophile scavenger 2-hydroxybenzylamine (2-HOBA) attenuates gastric cancer development caused by Helicobacter pylori
AP Gobert, M Asim, TM Smith, KJ Williams… - Biomedicine & …, 2023 - Elsevier
Stomach cancer is a leading cause of cancer death. Helicobacter pylori is a bacterial gastric
pathogen that is the primary risk factor for carcinogenesis, associated with its induction of …
pathogen that is the primary risk factor for carcinogenesis, associated with its induction of …