Leprosy is caused by Mycobacterium leprae (M. leprae) and M. lepromatosis, an obligate
intracellular organism, and over 200,000 new cases occur every year. M. leprae parasitizes …

Regulatory T-cells (Tregs) act at the interface of host and pathogen interactions in human
infectious diseases. Tregs are induced by a wide range of pathogens, but distinct effects of …

Leprosy is an infectious disease that may present different clinical forms depending on host
immune response to Mycobacterium leprae. Several studies have clarified the role of …

M1 macrophages release proinflammatory factors during inflammation. They transit to an M2
phenotype and release anti-inflammatory factors to resolve inflammation. An imbalance in …

Leprosy is a chronic infectious disease whose evolution involves complex immune
mechanisms of the host that influence the clinical presentation of the disease. For many …

Leprosy is a disease caused by Mycobacterium leprae (ML) with diverse clinical
manifestations, which are strongly correlated with the host's immune response. Skin lesions …

We recently showed that M ycobacterium leprae (ML) is able to induce lipid droplet
formation in infected macrophages. We herein confirm that cholesterol (Cho) is one of the …

Regulatory T (Treg) cells are known for their role in maintaining self-tolerance and balancing
immune reactions in autoimmune diseases and chronic infections. However, regulatory …

Iron homeostasis and macrophage biology are closely interconnected. On the one hand,
iron exerts multiple effects on macrophage polarization and functionality. On the other hand …

Leprosy is a chronic infectious disease that may present different clinical forms according to
the immune response of the host. Levels of IFN-γ are significantly raised in paucibacillary …