IgA nephropathy (IgAN), the most prevalent primary glomerulonephritis worldwide, carries a
considerable lifetime risk of kidney failure. Clinical manifestations of IgAN vary from …

IgA nephropathy (IgAN) is an important cause of ESKD for which there are no approved
therapies. A challenge for evaluating treatments for IgAN is the usual long time course for …

Complement activation has a role in the pathogenesis of IgA nephropathy, an autoimmune
disease mediated by pathogenic immune complexes consisting of galactose-deficient IgA1 …

IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide
and a common cause of end-stage renal disease. Evaluation of a kidney biopsy is …

IgA nephropathy is defined by the presence of IgA-dominant or co-dominant immune
deposits within glomeruli. Biopsy specimens meeting these diagnostic criteria have a range …

The complement cascade comprises soluble and cell surface proteins and is an important
arm of the innate immune system. Once activated, the complement system rapidly generates …

IgA nephropathy (IgAN) is common and often progresses to end stage renal disease. IgAN
encompasses a wide range of histology and clinical features. IgAN pathogenesis is …

IgA nephropathy (IgAN) is the most common primary glomerulonephritis, frequently leading
to end-stage renal disease, as there is no disease-specific therapy. IgAN is diagnosed from …

Immunoglobulin A (IgA) nephropathy (IgAN) is the most common type of primary
glomerulonephritis, often progressing to renal failure. IgAN is triggered by IgA deposition in …

IgA nephropathy remains the most common primary glomerular disease worldwide. It affects
children and adults of all ages, and is a leading cause of end-stage kidney disease, making …