Rhythms of life: circadian disruption and brain disorders across the lifespan

RW Logan, CA McClung - Nature Reviews Neuroscience, 2019 - nature.com
Many processes in the human body—including brain function—are regulated over the 24-
hour cycle, and there are strong associations between disrupted circadian rhythms (for …

Circadian and sleep dysfunction in Alzheimer's disease

MS Uddin, D Tewari, A Al Mamun, MT Kabir… - Ageing Research …, 2020 - Elsevier
Alzheimer's disease (AD) is a devastating and irreversible cognitive impairment and the
most common type of dementia. Along with progressive cognitive impairment, dysfunction of …

Circadian disturbances in Alzheimer's disease progression: a prospective observational cohort study of community-based older adults

P Li, L Gao, A Gaba, L Yu, L Cui, W Fan… - The Lancet Healthy …, 2020 - thelancet.com
Background Circadian disturbances are commonly seen in people with Alzheimer's disease
and have been reported in individuals without symptoms of dementia but with Alzheimer's …

[HTML][HTML] Gamma oscillations in Alzheimer's disease and their potential therapeutic role

A Traikapi, N Konstantinou - Frontiers in systems neuroscience, 2021 - frontiersin.org
Despite decades of research, Alzheimer's Disease (AD) remains a lethal neurodegenerative
disorder for which there are no effective treatments. This review examines the latest …

[HTML][HTML] An update on the use of gamma (multi) sensory stimulation for Alzheimer's disease treatment

V Manippa, A Palmisano, M Filardi, D Vilella… - Frontiers in Aging …, 2022 - frontiersin.org
Alzheimer's disease (AD) is characterized by reduced fast brain oscillations in the gamma
band (γ,> 30 Hz). Several animal studies show that inducing gamma oscillations through …

[HTML][HTML] Sleep disorders and Alzheimer's disease pathophysiology: The role of the Glymphatic System. A scoping review

K Astara, A Tsimpolis, K Kalafatakis… - Mechanisms of ageing …, 2024 - Elsevier
Background Alzheimer's disease (AD) is highly intertwined with sleep disturbances
throughout its whole natural history. Sleep consists of a major compound of the functionality …

[HTML][HTML] Correlation between the gut microbiome and neurodegenerative diseases: a review of metagenomics evidence

X Liu, Y Liu, J Liu, H Zhang, C Shan… - Neural Regeneration …, 2024 - journals.lww.com
A growing body of evidence suggests that the gut microbiota contributes to the development
of neurodegenerative diseases via the microbiota-gut-brain axis. As a contributing factor …

Dysfunction of circadian and sleep rhythms in the early stages of Alzheimer's disease

L Rigat, K Ouk, A Kramer, J Priller - Acta Physiologica, 2023 - Wiley Online Library
Dysfunction of circadian and sleep rhythms is an early feature of many neurodegenerative
diseases. Alzheimer's disease (AD) is a progressive neurodegenerative disorder resulting in …

[HTML][HTML] The clock modulator Nobiletin mitigates astrogliosis‐associated neuroinflammation and disease hallmarks in an Alzheimer's disease model

M Wirianto, CY Wang, E Kim, N Koike… - The FASEB …, 2022 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is a devastating neurodegenerative disorder, and there is a
pressing need to identify disease‐modifying factors and devise interventional strategies. The …

Sleep, orexin and cognition

B Toor, LB Ray, A Pozzobon, SM Fogel - The Orexin System. Basic …, 2021 - karger.com
Orexins regulate a wide variety of biological functions, most notably the sleep-wake cycle,
reward and stress processing, alertness, vigilance, and cognitive functioning. Alterations of …