Characterizing the proteome composition of organelles and subcellular regions of living
cells can facilitate the understanding of cellular organization as well as protein interactome …

Our understanding of the genetic mechanisms that underlie biological processes has relied
extensively on loss-of-function (LOF) analyses. LOF methods target DNA, RNA or protein to …

Elevated reactive oxygen species (ROS) induce the formation of lipids in neurons that are
transferred to glia, where they form lipid droplets (LDs). We show that glial and neuronal …

Abstract Since 1992, FlyBase (flybase. org) has been an essential online resource for the
Drosophila research community. Concentrating on the most extensively studied species …

We generated a library of~ 1000 Drosophila stocks in which we inserted a construct in the
intron of genes allowing expression of GAL4 under control of endogenous promoters while …

The anatomy of many neural circuits is being characterized with increasing resolution, but
their molecular properties remain mostly unknown. Here, we characterize gene expression …

Suppressing sensory arousal is critical for sleep, with deeper sleep requiring stronger
sensory suppression. The mechanisms that enable sleeping animals to largely ignore their …

The Drosophila genome contains> 13000 protein-coding genes, the majority of which
remain poorly investigated. Important reasons include the lack of antibodies or reporter …

Genetically encoded effectors are important tools for probing cellular function in living
animals, but improved methods for directing their expression to specific cell types are …

At presynaptic active zones (AZs), conserved scaffold protein architectures control synaptic
vesicle (SV) release by defining the nanoscale distribution and density of voltage-gated …