It is well established that alterations in phosphate metabolism have a profound effect on
hard and soft tissues of the oral cavity. The present-day clinical form of osteonecrosis of the …

Abstract Purpose of Review SARS-CoV-2 drove the catastrophic global phenomenon of the
COVID-19 pandemic resulting in a multitude of systemic health issues, including bone loss …

Osteoarthritis (OA), long considered a primary disorder of articular cartilage, is commonly
associated with subchondral bone sclerosis. However, the cellular mechanisms responsible …

Abstract Purpose of Review SARS-CoV-2 infection, the culprit of the COVID-19 pandemic,
has been associated with significant long-term effects on various organ systems, including …

Poor bone quality is a major factor in skeletal fragility in elderly individuals. The molecular
mechanisms that establish and maintain bone quality, independent of bone mass, are …

Osteocytes can resorb as well as replace bone adjacent to the expansive lacunar-
canalicular system (LCS). Suppressed LCS remodeling decreases bone fracture toughness …

Abstract Purpose of Review In perilacunar/canalicular remodeling (PLR), osteocytes
dynamically resorb, and then replace, the organic and mineral components of the …

Osteocytes are dynamic, bone matrix-remodeling cells that form an intricate network of
interconnected projections through the bone matrix, called the lacunar-canalicular system …

Abstract Purpose of Review The goal of this review is to summarize recent findings related to
modifications in osteocyte lacunar and canalicular morphology due to physiological and …

Bone fragility is the product of defects in bone mass and bone quality, both of which show
sex‐specific differences. Despite this, the cellular and molecular mechanisms underpinning …