Vulnerable neural systems and the borderland of brain aging and neurodegeneration

W Jagust - Neuron, 2013 - cell.com
Brain aging is characterized by considerable heterogeneity, including varying degrees of
dysfunction in specific brain systems, notably a medial temporal lobe memory system and a …

The effects of exercise on dopamine neurotransmission in Parkinson's disease: targeting neuroplasticity to modulate basal ganglia circuitry

GM Petzinger, DP Holschneider, BE Fisher… - Brain …, 2015 - content.iospress.com
Animal studies have been instrumental in providing evidence for exercise-induced
neuroplasticity of corticostriatal circuits that are profoundly affected in Parkinson's disease …

Baseline and longitudinal grey matter changes in newly diagnosed Parkinson's disease: ICICLE-PD study

E Mak, L Su, GB Williams, MJ Firbank, RA Lawson… - Brain, 2015 - academic.oup.com
Mild cognitive impairment in Parkinson's disease is associated with progression to dementia
(Parkinson's disease dementia) in a majority of patients. Determining structural imaging …

The default mode network and cognition in Parkinson's disease: A multimodal resting‐state network approach

MC Ruppert, A Greuel, J Freigang… - Human brain …, 2021 - Wiley Online Library
Involvement of the default mode network (DMN) in cognitive symptoms of Parkinson's
disease (PD) has been reported by resting‐state functional MRI (rsfMRI) studies. However …

Prefrontal dopamine signaling and cognitive symptoms of Parkinson's disease

NS Narayanan, RL Rodnitzky, EY Uc - Reviews in the Neurosciences, 2013 - degruyter.com
Cognitive dysfunction is a common symptom of Parkinson's disease (PD) that causes
significant morbidity and mortality. The severity of these symptoms ranges from minor …

[图书][B] Neuropsychology: From theory to practice

D Andrewes - 2015 - taylorfrancis.com
The second edition of this comprehensive textbook for students of Neuropsychology gives a
thorough overview of the complex relationship between brain and behaviour. With an …

Risk factors associated with the epilepsy treatment gap in Kilifi, Kenya: a cross-sectional study

CK Mbuba, AK Ngugi, G Fegan, F Ibinda… - The Lancet …, 2012 - thelancet.com
Background Many people with epilepsy in low-income countries do not receive appropriate
biomedical treatment. This epilepsy treatment gap might be caused by patients not seeking …

Multi‐omic landscaping of human midbrains identifies disease‐relevant molecular targets and pathways in advanced‐stage Parkinson's disease

L Caldi Gomes, A Galhoz, G Jain… - Clinical and …, 2022 - Wiley Online Library
Background Parkinson's disease (PD) is the second most common neurodegenerative
disorder whose prevalence is rapidly increasing worldwide. The molecular mechanisms …

[HTML][HTML] FDG-PET hypometabolism is more sensitive than MRI atrophy in Parkinson's disease: a whole-brain multimodal imaging meta-analysis

F Albrecht, T Ballarini, J Neumann, ML Schroeter - NeuroImage: Clinical, 2019 - Elsevier
Recently, revised diagnostic criteria for Parkinson's disease (PD) were introduced (Postuma
et al., 2015). Yet, except for well-established dopaminergic imaging, validated imaging …

Altered brain metabolic connectivity at multiscale level in early Parkinson's disease

A Sala, SP Caminiti, L Presotto, E Premi, A Pilotto… - Scientific reports, 2017 - nature.com
To explore the effects of PD pathology on brain connectivity, we characterized with an
emergent computational approach the brain metabolic connectome using [18F] FDG-PET in …